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Mostrando ítems 1001-1010 de 1014
Artículo
PTPN13 and beta-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche
(Elsevier, 2015)
The regulation of hematopoietic stem cells (HSCs) depends on the integration of the multiple signals received from the bone marrow niche. We show the relevance of the protein tyrosine phosphatase PTPN13 and b-catenin as ...
Artículo
High incidence of pandrug-resistant Acinetobacter baumannii isolates collected from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial
(Oxford Academic, 2017-12)
Objectives: To investigate the molecular epidemiology, antimicrobial susceptibility and carbapenem resistance determinants of Acinetobacter baumannii isolates from respiratory tract samples of patients diagnosed with ...
Artículo
A lipopolysaccharide-free outer membrane vesicle vaccine protects against Acinetobacter baumannii infection
(Elsevier, 2020-01)
Outer membrane vesicles (OMVs) were isolated from an Acinetobacter strain deficient in lipopolysaccharide (LPS) due to a mutation in lpxD (IB010). Two immunizations with 10 µg of IB010 OMVs elicited total IgG, IgM, IgG1 ...
Artículo
Impacto de la enseñanza integrada de la patología médico-quirúrgica en pequeños grupos basada en la resolución de problemas en el aprendizaje de la medicina
(Universidad de Sevilla, 2023)
Objetivos. El presente proyecto parte de la hipótesis de que un programa docente basado en la enseñanza integrada y en el aprendizaje basado en problemas constituye una forma innovadora de docencia que alcanza una mayor ...
Artículo
Role of EpCAM+ CD133+ extracellular vesicles in steatosis to steatohepatitis transition in NAFLD
(Wiley, 2023)
Background and Aims Extracellular vesicles (EVs) have emerged as a potential source of circulating biomarkers in liver disease. We evaluated circulating AV+ EpCAM+ CD133+ EVs as a potential biomarker of the transition ...
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Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia
(Elsevier, 2018-11)
Objective: To evaluate the ability of the BioFire FilmArray Blood Culture Identification (BCID) panel to rapidly detect pathogens producing late-onset ventilator-associated pneumonia (VAP), a severe infection often ...
Artículo
Immunization with lipopolysaccharide-free outer membrane complexes protects against Acinetobacter baumannii infection
(Elsevier, 2018-07-05)
Outer membrane complex (OMC) vaccines, which contain antigens from the bacterial outer membrane, have been developed for multiple Gram-negative bacteria. However, OMC vaccines demonstrate high endotoxin activity due to the ...
Artículo
Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii
(Taylor & Francis, 2018)
Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used ...
Artículo
Cutaneous malignant melanoma mortality in Andalusia from 1979 to 2018. Toward new perspectives?
(Wiley, 2021)
Malignant melanoma accounts for 80% of deaths due to skin cancer. Its incidence is globally increasing. However, melanoma mortality seems to be decreasing. The aim of this study was to analyze mortality rates due to melanoma ...
Artículo
Cutaneous malignant melanoma mortality in Spain from 1979 to 2018. Trends and new perspectives in the immunotherapy era
(Wiley, 2021)
Background: Recent studies suggest that cutaneous melanoma mortality rates in Spain are stabilizing and even decreasing in younger cohorts. Objectives: To analyse mortality rates of melanoma from the last 40 years, ...