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Artículo
Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy
(2018-01-31)
Hepatitis C virus (HCV) infection has been related to increased risk of development of hepa tocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we ...
Artículo
Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression
(2012)
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited. Despite the growing number of studies linking the ...
Tesis Doctoral
El antígeno de células neoplásicas escamosas (SCCA) solo o formando el complejo SCCA-igM es un biomarcador precoz de carcinoma hepatocelular.
(2018-07-11)
Background: Hepatocellular carcinoma (HCC) represents more than 90% of primary liver cancers and is a major health problem. Every year more than 6.7 million deaths and 10.9 million new cancer cases were diagnosed. Early ...
Artículo
Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients in Spain
(Lippincott, Williams & Wilkins, 2020)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) presents many public health challenges, including a substantial impact on healthcare resource utilization and costs. ...
Artículo
Patente. Invención
Uso del compuesto N-fenil-N-(3-metil-2-butenil)tiourea para la elaboración de medicamentos destinados al tratamiento de la encefalopatía hepática
(Oficina Española de Patentes y Marcas (OEPM), 2012-05-09)
La presente invención se refiere a una composición farmacéutica que comprende el compuesto N-fenil-N- (3-metil-2-butenil)tiourea y al uso del compuesto Nfenil-N-(3-metil-2-butenil)tiourea y de dicha composición farmacéutica ...
Artículo
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
(Elsevier, 2020)
Herein, we describe, for the first time, 3 different clinical courses of acute decompensation (AD) of cirrhosis after hospital admission. The first clinical course includes patients who develop acute-on-chronic liver failure ...
Artículo
Stratification of patients in NASH clinical trials: a pitfall for trial success
(Elsevier, 2020)
Identifying the most effective therapeutic intervention in patients with NAFLD is challenging. Precise stratification in clinical trials is key to ensuring the inclusion of patients who will benefit (and not those who will ...
Artículo
The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease
(Elsevier, 2020)
Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is closely associated with obesity, type 2 diabetes, hypertension and dyslipidaemia, represents an increasing global public health challenge. There ...
Tesis Doctoral
Genes y encefalopatía hepática: propuesta de una huella genética para la valoración del riesgo
(2019-06-06)
Introducción y objetivos: Determinar el impacto de los factores genéticos en el desarrollo de encefalopatía hepática (EH) en pacientes con cirrosis. Metodología: Se incluyeron pacientes con cirrosis hepática compensada [n=434; ...