Fisiología Médica y Biofísica: Envíos recientes
Mostrando ítems 41-60 de 525
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Impact of COVID-19 on liver disease: From the experimental to the clinic perspective.
(Baishideng Publishing Group Inc, 2021)Coronavirus disease 2019 (COVID-19) has caused a global pandemic unprecedented in over a century. Although severe acute ...
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Sushi domain-containing protein 4 controls synaptic plasticity and motor learning
(2021)Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled ...
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Innate Immune Receptors, Key Actors in Cardiovascular Diseases
(Elsevier on behalf of the American College of Cardiology Foundation, 2020)Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with ...
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Cellular adaptation to oxygen deficiency beyond the Nobel award
(Willey, 2020)Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the ...
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
(Nature Portfolio, 2020)Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for ...
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Tesis Doctoral
Characterization of the nigrostriatal pathway in Parkinson's Disease mice models of overexpression of human alpha-synuclein and LRRK2 mutants
(2023-09-05)Parkinson's disease (PD) is a long-term neurodegenerative disease with a complex array of symptoms and signs, involving ...
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Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α
(Frontiers Research Foundation, 2020)Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical ...
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Association of high microvessel alpha(v)beta(3) and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126
(2016-10-26)Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic ...
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The RhoB small GTPase in physiology and disease
(2016-10-23)RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique ...
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Multiple Holdouts With Stability: Improving the Generalizability of Machine Learning Analyses of Brain–Behavior Relationships
(Elsevier, 2020)BACKGROUND: In 2009, the National Institute of Mental Health launched the Research Domain Criteria, an attempt to move ...
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Conservative and disruptive modes of adolescent change in human brain functional connectivity
(National Academy of Sciences, 2020)Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to ...
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Practical Application of Networks in Neurosurgery: Combined 3-Dimensional Printing, Neuronavigation, and Preoperative Surgical Planning
(Elsevier, 2020)BACKGROUND: A plethora of cutting-edge neuroimaging analyses have been developed and published, yet they have not hitherto ...
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Ketotifen is a microglial stabilizer by inhibiting secretory vesicle acidification
(Elsevier, 2023)Aims: Microglia survey the brain environment by sensing alarm signals to provide the first line of defense against injury ...
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Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington's disease model mice
(NATURE PUBLISHING GROUP, 2023)Huntington’s disease (HD) is a progressive, neurodegenerative disease caused by a CAG triplet expansion in huntingtin. ...
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Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
(Nature Portfolio, 2020)Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain ...
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Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes
(Elsevier, 2020)Background: Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits, but the ...
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A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder
(Nature Portfolio, 2020)Understanding heterogeneity is an important goal on the path to precision medicine for autism spectrum disorders (ASD). ...
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What Is the Link Between Attention-Deficit/ Hyperactivity Disorder and Sleep Disturbance? A Multimodal Examination of Longitudinal Relationships and Brain Structure Using Large-Scale Population-Based Cohorts
(Elsevier, 2020)BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) comorbid with sleep disturbances can produce profound disruption ...
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Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice
(MDPI, 2021)α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications ...
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Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023-03-14)Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of ...