Fisiología Médica y Biofísica: Recent submissions
Now showing items 1-20 of 543
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PhD Thesis
Papel de Reelina y ADAMTS2 en modelos experimentales de esquizofrenia en ratón
(2024-06-19)La esquizofrenia es una enfermedad mental grave con un 0.6-0.8% de prevalencia mundial, que se inicia durante la adolescencia ...
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Article
Presenilin/γ-Secretase Regulates Neurexin Processing at Synapses
(Public Library of Science, 2011-04-29)Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during ...
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Article
Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons
(Elsevier, 2008-02-15)Gene transfer methods for efficient co-expression of exogenous proteins in neurons are crucial tools towards the understanding ...
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Article
Rare variants analysis of neurexin-1β in autism reveals a novel start codon mutation affecting protein levels at synapses
(Lippincott, Williams & Wilkins, 2013-08-07)Neurexins are synaptic plasma membrane proteins encoded by three genes (NRXN1, -2, -3) with alternative promoters. Mutations ...
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A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function
(Elsevier, 2015-09-03)Neuroligins (NLs) are cell-adhesion proteins that regulate synapse formation and function. Neuroligin 1 (NL1) promotes the ...
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Article
Molecular and Cellular Mechanisms of Synaptopathies
(Wiley Open Access, 2017-04-30)Synapses, contact points between neurons, are essential elements supporting the ability of neurons to communicate and to ...
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Article
Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release
(Society for Neuroscience, 2018-01-24)Proteolytic processing of synaptic adhesion components can accommodate the function of synapses to activity-dependent ...
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Article
A Neuroligin-1 mutation associated with Alzheimer’s disease produces memory and age-dependent impairments in hippocampal plasticity
(Cell Press, 2023-05-13)Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical ...
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Article
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024-07-24)Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...
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Article
The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells
(Frontiers Media, 2018-03-21)Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. ...
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PhD Thesis
Characterization of undifferentiated neuroblastoma cells and their contribution to aggressiveness
(2024-04-12)Neuroblastoma (NB) represents the most prevalent extracranial solid tumor among children, originating from cells within ...
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PhD Thesis
Remodelado de la entrada de calcio operada por los reservorios y su regulación por micrornas en la reestenosis vascular
(2024-04-24)La cardiopatía isquémica constituye la principal causa de muerte en relación con las enfermedades cardiovasculares. Su ...
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Article
Valor pronóstico de la bioimpedancia eléctrica medida con el dispositivo IVOL en la insuficiencia cardiaca aguda
(Elsevier, 2024)Introducción y objetivos: La evaluación actual de la insuficiencia cardiaca (IC) aguda no permite predecir adecuadamente ...
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Article
Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells
(2016-08-07)Systemic treatments for hepatocellular carcinoma (HCC) have been largely unsuccessful. This study investigated the ...
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Article
An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
(Wiley, 2024)Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer ...
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Article
Redox signaling in acute oxygen sensing
(Elsevier, 2017-04-26)Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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Article
NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
(Impact Journals LLC, 2017-09-08)The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction ...
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Article
A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...
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Article
IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner
(Willey, 2022)Insulin-like growth factor-I (IGF-I) signaling plays a key role in neuroinflammation. Here we show that IGF-1 also regulates ...
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Article
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...