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Artículo
Rat Adrenal Chromaffin Cells Are Neonatal CO2 Sensors
(2005)
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric recordings, we measured catecholamine (CAT) secretion from cells inAMslices of neonatal and adult ...
Tesis Doctoral
GDNF y cuerpo carotídeo: implicaciones funcionales y uso en terapia celular
(2007-04-19)
El proyecto que se desarrolla en esta Tesis Doctoral se ha centrado en el estudio de los mecanismos celulares y moleculares por los que el trasplante de cuerpo carotídeo (CC) produce recuperación en modelos experimentales ...
Artículo
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats
(2003)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with carotid body (CB) cell aggregates. Amelioration of their motor syndrome is a result of the trophic ...
Artículo
Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation
(2005)
Glial cell line-derived neurotrophic factor (GDNF) exerts a notable protective effect on dopaminergic neurons in rodent and primate models of Parkinson’s disease (PD). The clinical applicability of this therapy is, however, ...
Artículo
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression
(Elsevier, 2007)
O2 is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, measurements of O 2 permeability of lipid bilayers have indicated that it is much lower than previously ...
Tesis Doctoral
Quimiorrecepción del CO2 en la médula adrenal y facilitación de la permeabilidad a O2 por la acuaporina-1
(2007-02-02)
El desarrollo de esta Tesis se ha centrado en el estudio de los mecanismos celulares que permiten la quimiotransducción de O2 y CO2 en órganos como el cuerpo carotídeo y la médula adrenal. Teniendo en cuenta las evidencias ...