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Artículo
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. ...
Capítulo de Libro
A pathophysiological view of the neural stem cell niche
(Nova Science Publishers, INC. U.S., 2011)
Neural stem cells were described in the nervous system some decades ago as being responsible for adult neurogenesis and hence the structural plasticity in the tissue. These cells reside in specialized niches where they are ...
Tesis Doctoral
Papel de la quinasa humana VRK1 en la biología del neuroblastoma
(2020-01-29)
El neuroblastoma es el tumor extracraneal sólido más frecuente en la infancia. Su comportamiento es muy heterogéneo, pudiéndose dar desde regresión espontánea hasta tumores metastásicos muy agresivos. Uno de los ...
Artículo
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to ...
Artículo
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
(Springer, 2018-11-29)
Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. A complex homeostatic oxygen-sensing system has evolved in these organisms, including detectors and ...
Tesis Doctoral
Hipertrofia del cuerpo carotídeo en hipoxia crónica: mecanismos de activación, proliferación y diferenciación de los progenitores neurales en el sistema nervioso periférico
(2014-04-25)
The goal of this doctoral thesis is to achieve a better understanding of the biology and behavior of the recently discovered adult carotid body neural stem cells. The work focuses on two main objectives. First, to study ...
Artículo
Neurotransmitter Modulation of Carotid Body Germinal Niche
(MDPI AG, 2020-11-03)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which ...
Artículo
An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia
(CELL PRESS, 2014-01-16)
Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells ...
Tesis Doctoral
Plasticidad fisiológica de las células madre del cuerpo carotídeo adulto: caracterización del linaje mesectodérmico
(2015-07-01)
El cuerpo carotídeo (CB), un órgano quimiosensor derivado de la cresta neural, permite la adaptación a la hipoxia crónica mediante neurogénesis y angiogénesis. Recientemente se ha descrito en nuestro grupo que ambos procesos ...
Capítulo de Libro
Progenitor Cell Heterogeneity in the Adult Carotid Body Germinal Niche
(Springer, 2019)
Somatic stem cells confer plasticity to adult tissues, permitting their maintenance, repair and adaptation to a changing environment. Adult germinal niches supporting somatic stem cells have been thoroughly characterized ...