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Mostrando ítems 1-7 de 7
Artículo
Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
(Public Library of Science, 2016-07-25)
One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at ...
Artículo
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease
(2011)
In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein huntingtin (htt) leads to neurodegeneration in specific brain areas. Neurons degenerating in HD develop ...
Artículo
A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss
(Wiley-Blackwell Publishing Ltd., 2016)
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we ...
Artículo
Cysteine String Protein- Prevents Activity-Dependent Degeneration in GABAergic Synapses
(2010)
The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that could compromise nerve terminal function. This supposition and the molecular mechanisms that might ...
Tesis Doctoral
Identificación de una firma inmunohistoquímica con valor predictivo en el carcinoma infiltrante de mama de tipo no especial (NST)
(2015-05-28)
Introducción: En la actualidad, el cáncer de mama es la neoplasia maligna más común en la mujer, siendo la causa principal de muerte en mujeres entre los 35 y 55 años en todo el mundo. La identificación en el cáncer de ...
Tesis Doctoral
Single‐cell transcriptomic and functional characterization of cortical parvalbumin interneurons in a novel conditional knock‐out mouse lacking CSPα/DNAJC5
(2019-07-05)
Neurodegenerative diseases are progressive disorders currently without cure. Indeed, the molecular mechanisms underlying synaptic and neuronal degeneration are poorly understood. Cysteine String Protein‐α/DNAJC5 (CSPα/DNAJC5) ...
Tesis Doctoral
Presynaptic calcium dynamics, neuronal excitability and synaptic vesicle Cycle in central synapses lacking cysteine string protein-alpha (CSP-ALPHA).
(2017-12-22)
Cysteine String Protein-α (CSP-α) is a molecular co-chaperone of the synaptic vesicles that prevents presynaptic degeneration. The role of CSP-α in the machinery of calcium dependent release of neurotransmitter from synaptic ...