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Tesis Doctoral
Artículo
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2016)
Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle cells (VSMC). Several studies have also determined the relevant role of store-operated Ca2 channels ...
Tesis Doctoral
Implicación de la entrada de calcio regulada por los reservorios en la vasoconstricción y proliferación inducida por urotensina-ii en aorta
(2012-06-26)
En los últimos años, la terminación de la primera parte del Proyecto Genoma Humano ha traído consigo la identificación de una gran variedad de péptidos y proteínas noveles, entre los que se encuentran un gran número de ...
Artículo
Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery Role of EPAC2 and ERK12
(Public Library of Science, 2016)
Urocortin-1 (Ucn-1) is an endogenous peptide that protects heart from ischemia and reperfusion (I/R) injuries. Ucn-1 is known to prevent cardiac cell death, but its role in the transcription of specific genes related to ...
Artículo
Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells
(2019-10-23)
Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and protein kinase A ...
Artículo
TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure
(MDPI AC, 2018-09-14)
Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, ...
Artículo
EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
(S. Karger AG, 2018-11-28)
Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved in the regulation of SOCE, SARAF prevents spontaneous activation of SOCE and modulates STIM1 ...
Artículo
STIM and Orai1 Variants in Store-Operated Calcium Entry
(Frontiers Research Foundation, 2016-01-13)
Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma ...
Artículo
Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
(Frontiers Research Foundation, 2018-07-03)
Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, ...