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Editorial: Out-of-field second primary cancer induction Dosimetry and modelling
(Frontiers Media, 2022-12-05)
Second primary cancer induction is a growing concern, particularly for the younger cancer patient population with a longer life expectancy, as demonstrated by the increasing number of publications on the topic. Still, there ...
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BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
(NATL ACAD SCIENCES, 2019-07-18)
Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and likewise, affects the development of the neuromuscular system. Besides its neuronal origin, BDNF ...
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Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
(Frontiers Media S.A., 2022)
The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. ...
PhD Thesis
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Transcriptional Regulation and Epigenetic Mechanisms Underlying Host-Parasite Interactions in Human Malaria
(2022-11-04)
Human malaria is one of the most important infectious diseases and a major cause of death and poverty worldwide. It is caused by protozoan parasites of the genus Plasmodium that are transmitted by the bites of mosquitoes ...
PhD Thesis
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Efectos de los fotoperiodos, administración de estrógenos y castración sobre la actividad peptidásica y metabolismo oxidativo en hipotálamo y corteza cerebral
(1978-05-18)
CONCLUSIONES: 1. En el grupo de animales controles la actividad LAP es mayor en el hipotálamo que en la corteza. La actividad enzimática oxidativa es mayor en el hipotálamo para ICDH y menor para MDH. 2. La administración ...
PhD Thesis
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Simulaciones biofísicas mediante elementos finitos de procesos de criopreservación y recalentamiento en material biológico
(2022-06-03)
En la criopreservación de material biológico se utilizan las bajas temperaturas para detener los procesos metabólicos celulares, intentando evitar el daño celular debido a la formación de hielo y las altas concentraciones ...
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Statistical Agnostic Mapping: A framework in neuroimaging based on concentration inequalities
(Elsevier, 2021-02)
In the 1970s a novel branch of statistics emerged focusing its effort on the selection of a function for the pattern recognition problem that would fulfill a relationship between the quality of the approximation and ...
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Considerations on diagnosis and surveillance measures of PTEN hamartoma tumor syndrome clinical and genetic study in a series of Spanish patients
(BMC, 2022-02-28)
Background The limited knowledge about the PTEN hamartoma tumor syndrome (PHTS) makes its diagnosis a challenging task. We aimed to define the clinical and genetic characteristics of this syndrome in the Spanish population ...
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Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
(Elsevier, 2020-03-16)
Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals, evasion of apoptosis,cellular stress, and sustained angiogenesis, invasiveness and metastatic potential. Cancer cells adequately ...
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Role of the holoenzyme PP1-SPN in the dephosphorylation of the rb family of tumor suppressors during cell cycle
(MDPI, 2021-05-06)
Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance ...