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PhD Thesis
Estudios sobre el papel del área tegmental ventral y de las regiones dopaminérgicas rostral lineal y periacueductal del mesencéfalo en la adicción y analgesia opiáceas en ratas
(2005-11-09)
El número medio de cada tipo celular fue de 129,431,3 células grandes de la PAG ventrolateral, 305,843,5 células periacueductales de la PAG y 1441,4210 células pequeñas de la región RLi/PAG ventral. 3. En las neuronas ...
Article
Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The tyrosine kinase inhibitor Sorafenib (Sfb) remains the globally accepted treatment for advanced HCC. ...
Chapter of Book
Clinical applications of cell therapy
(Edikamed, 2010)
Article
Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body
(1989)
Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole cell variant of the patch-clamp technique. Type II cells only have a tiny, slowly activating outward ...
Article
Native α-synuclein, 3-nitrotyrosine proteins, and patterns of nitro-α-synuclein-immunoreactive inclusions in saliva and submandibulary gland in parkinson’s disease
(MDPI, 2021-05-01)
Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-αsynuclein (3-NT-αSyn), hold promise as biomarkers for idiopathic Parkinson’s disease (IPD). Nitrative stress that is characterized by an ...
Article
Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept
(Nature Publishing Group, 2022)
The human brain is a highly plastic ‘complex’ network—it is highly resilient to damage and capable of self-reorganisation after a large perturbation. Clinically, neurological deficits secondary to iatrogenic injury have ...
Patent
Composición que comprende gdnf y tgf-beta1 y su uso para el tratamiento de una enfermedad neurológica.
(Oficina Española de Patentes y Marcas , 2011-08-01)
Composición que comprende GDNG y TGF-?1 y su uso para el tratamiento de enfermedad neurológica.Composición farmacéutica que comprende el factor neurotrófico derivado de la glía (GDNF) y el factor transformante beta 1 ...
PhD Thesis
Imagen 3D en Cardiopatías Congénitas
(2023-05-19)
Las cardiopatías congénitas precisan de una mmuc10sa evaluación tridimensional para determinar las opciones de tratamiento y garantizar el éxito del procedimiento a realizar. A pesar de que el método diagnóstico más habitual ...
Article
Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells
(Springer Nature, 2020)
Sorafenib and Regorafenib are the recommended first- and second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib and Cabozantinib have shown non-inferior antitumoral activities compared ...
Article
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
(Elsevier, 2015)
Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a ...