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Artículo
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CSP alpha-deficiency causes massive and rapid photoreceptor degeneration
(2006)
Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40-type cochaperones. Previous studies showed that deletion of CSP_ in mice leads to massive lethal ...
Tesis Doctoral
Artículo
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Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?
(Oxford University Press (OUP), 2021)
Tesis Doctoral
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Xenotrasplantes de cuerpo carotideo en ratones parkinsonianos inmunodeprimidos.
(2017-09-26)
Los trasplantes intraestriatales de cuerpo carotídeo (CC) han mostrado un claro efecto beneficioso en modelos animales de parkinsonismo, ejerciendo una acción trófica, mediada por la liberación del factor neurotrófico ...
Tesis Doctoral
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Radiobiología molecular en cáncer de pulmón de células no pequeñas: factores pronósticos y predictivos de respuesta
(2021-07-14)
El cáncer de pulmón de célula no pequeña (CPCNP) es la principal causa de muerte por cáncer a nivel mundial, generando un enorme impacto económico y social que no ha dejado de crecer en los últimos años. El tratamiento ...
Artículo
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SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology
(MDPI, 2021-06-21)
The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their similar structures and expression patterns, early studies of constitutive KO mice showing that SOS1-KO ...
Artículo
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Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study
(MDPI, 2020)
Healthy lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease the likelihood of developing metabolic syndrome (MetS). The aim of this study was to report main lifestyle components and ...
Artículo
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The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
(Springer, 2018-11-29)
Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. A complex homeostatic oxygen-sensing system has evolved in these organisms, including detectors and ...
Artículo
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Interspecies chimerism with mammalian pluripotent stem cells
(CELL PRESS, 2017)
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated ...
Artículo
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Regulation of oxygen sensing by ion channels
(2004)
O2 sensing is of critical importance for cell survival and adaptation of living organisms to changing environments or physiological conditions. O2-sensitive ion channels are major effectors of the cellular responses to ...