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Artículo
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Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity
(Elsevier, 2021-10-15)
Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the ...
Artículo
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Generation of human organs in pigs via interspecies blastocyst complementation
(Wiley-Blackwell Verlag GmbH, 2016-10-19)
More than eighteen years have passed since the first derivation of human embryonic stem cells (ESCs), but their clinical use is still met with several challenges, such as ethical concerns regarding the need of human embryos, ...
Artículo
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Multiple Functions of the Vesicular Proton Pump in Nerve Terminals
(Cell Press, 2010-12-22)
Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After vesicle exocytosis, continued operation of the vATPase would seem to serve no useful function. In this ...
Tesis Doctoral
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Estimation of risk associated to peripheral dose in patients undergoing radiotherapy treatment
(2012-07-21)
The induction of secondary cancer as a consequence of the radiotherapy treatment is an issue of concern nowadays. This fact makes relevant to consider all the dose delivered to the patient and, thus, it is necessary to ...
Artículo
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Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood
(Wiley Open Access, 2020-10-23)
Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more ...
Artículo
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Lesion covariance networks reveal proposed origins and pathways of diffuse gliomas
(Oxford University Press, 2021-12-04)
Diffuse gliomas have been hypothesized to originate from neural stem cells in the subventricular zone and develop along previously healthy brain networks. Here, we evaluated these hypotheses by mapping independent sources ...
Tesis Doctoral
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Nanotechnology approaches for improvoved vasoactive intestinal peptide based-drug delivery systems
(2014-01-08)
The specific purpose of this project is to study the feasibility as a proof of concept of different nanotechnology approaches in order to improve the drug delivery of the neuropeptide vasoactive intestinal peptide (VIP). ...
Artículo
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The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release
(Amer Soc Biochemistry Molecular Biology Inc, 2021)
Gene duplication generates new functions and traits, enabling evolution. Human-specific duplicated genes in particular are primary sources of innovation during our evolution although they have very few known functions. ...
Artículo
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Neodymium doped lanthanide fluoride nanoparticles as contrast agents for luminescent bioimaging and X-ray computed tomography
(Soc Española de Cerámica y Vidrio, 2022)
The synthesis of uniform neodymium-doped lanthanum trifluoride nanoparticles with lenticular shape and a mean diameter around 45 nm by using a homogeneous precipita- tion method is reported. The luminescent properties ...
Artículo
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Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
(OXFORD UNIV PRESS, 2010)
Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. Depending on the levels of SMN protein produced from a second SMN gene (SMN2), different forms of ...