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Artículo
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was ...
Artículo
Magnetofection as a new tool to study microglia biology
(Medknow Publications, 2019)
Artículo
Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
(BioMed Central, 2016)
Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral macrophages, which contribute to an ...
Artículo
Mitochondrial toxins and neurodegenerative diseases
(IMR Press, 2007)
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this ...
Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
(American Society for Clinical Investigation, 2022)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the ...
Artículo
PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity. (Erratum) Aging, 2015; 7(9): 629‐647.
(Impact Journals, 2016)
In this article, the additional author Aine Brigette Henley is added to this manuscript: http://www.impactaging.com/papers/v7/n9/pdf/100790.pdf.
Artículo
Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
(Wiley, 2023-11)
INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. ...
Artículo
Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated ...
Artículo
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin ...
Artículo
Caspase signalling controls microglia activation and neurotoxicity
(Springer Nature, 2011-04-11)
Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis of several neurodegenerative disorders. Activated microglia release pro-inflammatory factors that ...