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Artículo
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021-01-10)
Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal of extra cells during early developmental stages. Hence, an impairment of this process may thus ...
Artículo
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024-01-16)
Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether ...
Artículo
The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive ...