Now showing items 1-2 of 2
Caspase-8 inhibition represses initial human monocyte activation in septic shock model [Article]
(Impact Journals, 2016)
In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream ...
Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism [Article]
(BioMed Central, 2015)
Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was ...