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AuthorVitorica Ferrández, Francisco Javier (8)Gutiérrez Pérez, Antonia (5)Sánchez Mejías, Elisabeth (5)Sánchez Varo, Raquel María (5)Vizuete Chacón, María Luisa (5)Dávila Cansino, José Carlos (3)Fernández Valenzuela, Juan José (3)García León, Juan Antonio (3)Gutiérrez, Antonia (3)Jiménez Muñoz, Sebastián (3)... View MoreSubject
Alzheimer’s disease (12)
Microglia (5)Astrocytes (3)Neurodegeneration (3)Amyloid (2)Neuroinflammation (2)Oligodendrocytes (2)Tau (2)3D cultures (1)Abeta production (1)... View MoreDate Issued2022 (5)2018 (2)2021 (2)2012 (1)2019 (1)2020 (1)Funding agencyJunta de Andalucía (5)Instituto de Salud Carlos III (4)Ministerio de Ciencia e Innovación (MICIN). España (4)European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) (3)Universidad de Málaga (2)Alzheimer Association (1)Consejería de Economía y Conocimiento, Junta de Andalucía (1)European Union (UE). Marie Curie (1)Fundación La Marató-TV3. Cataluña. España (1)Instituto de Salud Carlos III PI18/01556, PI18/01557 (1)... View More
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus 

Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)
Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer’s patients and transgenic models at early ages. These axonal dystrophies ...
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Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation 

Carrillo Jiménez, Alejandro; Puigdellívol, Mar; Vilalta, Anna; Venero Recio, José Luis; Brown, Charles Guy; Burguillos García, Miguel Ángel (Frontiers Media, 2018)
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer’s disease (AD). The use of primary microglial cell cultures has proved to be a ...
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Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease 

Romero Molina, Carmen; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Mico, María; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional markers and transcriptomic profiles along the different brain regions as well as under injury or ...
Article
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Human Pluripotent Stem Cell-Derived Neural Cellsas a Relevant Platform for Drug Screening inAlzheimer’s Disease 

García León, Juan Antonio; Cáceres Palomo, Laura; Sánchez Mejías, Elisabeth; Mejías Ortega, Marina; Núñez Díaz, Cristina; Fernández Valenzuela, Juan José; Sánchez Varo, Raquel María; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (MDPI, 2020)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tanglesare prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still notfully understood, since different ...
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Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform 

García León, Juan Antonio; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Future Science Group, 2019)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies ...
Article
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Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner 

Bachiller, Sara; Hidalgo, Isabel; Garcia, M. G.; Boza Serrano, Antonio; Paulus, A.; Denis, Q.; Haikal, C.; Manouchehrian, O.; Klementieva, O.; Li, J. Y.; Pronk, C. J.; Gouras, G. K.; Deierborg, Tomas (BMC, 2022)
Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function ...
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Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease 

Muñoz Castro, Clara; Noori, Ayush; Magdamo, Colin G.; Li, Zhaozhi; Marks, Jordan D.; Frosch, Matthew P.; Das, Sudeshna; Hyman, Bradley T.; Serrano Pozo, Alberto (BMC, 2022)
Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or ...
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Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease 

Salvadores, Natalia; Moreno González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas Gómez, Laura; Escandón, Marcela; Jiménez Muñoz, Sebastián; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Soto, Claudio; Court, Felipe A. (BMC, 2022)
Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports point amyloid-β (Aβ) as the main etiologic agent that triggers AD. Although there is extensive ...
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Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease 

Gómez Arboledas, Ángela; Dávila Cansino, José Carlos; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley, 2018)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation ofcomponents of intermediate filaments, is a common feature in brains of Alzheimer’s patients. Reac-tive astrocytes are found in ...
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Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis 

Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Fernández Valenzuela, Juan José; Castro, Vanessa de; Mejías Ortega, Marina; Gómez Arboledas, Ángela; Jiménez, Sebastián; Sánchez Mico, María; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez, Antonia (Frontiers Media, 2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological ...
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