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AuthorAyala Gómez, Antonio (4)Ruano Caballero, Diego (3)Vitorica Ferrández, Francisco Javier (3)Argüelles Castilla, Sandro (2)Jiménez Muñoz, Sebastián (2)Venero Recio, José Luis (2)Abilés, Jimena (1)Aguayo, Eduardo (1)Aranda, Pilar (1)Araujo, Francisco (1)... View MoreSubjectAlzheimer (2)Neuroinflammation (2)3-NPA (1)Aging (1)Apoptosis (1)Autoimmunity (1)BDNF (1)ER-stress (1)Hippocampus (1)Hippocampus Aβ plaques (1)... View MoreDate Issued2006 (2)2009 (2)2000 (1)2002 (1)2005 (1)2007 (1)2008 (1)Funding agencyInstituto Naconal de Sanidad (INS) (1)Ministerio de Educación y Ciencia (MEC). España (1)Ministerio de Sanidad. España (1)
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Article
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Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders 

Chorny, Alejo; Gonzalez-Rey, Elena; Fernandez-Martin, Amelia; Pozo Pérez, David; Ganea, Doina; Delgado, Mario (National Academy of Sciences, 2005)
The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune-response-inducing T cell ...
Article
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Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex 

Martínez de Pablos, Rocío; Fernández Villarán, Ruth; Argüelles Castilla, Sandro; Herrera Carmona, Antonio José; Venero Recio, José Luis; Ayala Gómez, Antonio (Society for Neuroscience, 2006)
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear. ...
Article
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Inflammatory response in the hippocampus of PS1M146L/APP 751SL mouse model of Alzheimer's disease: Age-dependent switch in the microglial phenotype from alternative to classic 

Jiménez Muñoz, Sebastián; Baglietto Vargas, David; Caballero, Cristina M.; Moreno González, Inés; Torres Canalejo, Manuel; Sánchez Varo, Raquel María; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ...
Article
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Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study 

Abilés, Jimena; Pérez de la Cruz, Antonio Jesús; Castaño, José García; Rodríguez Elvira, Manuel; Aguayo, Eduardo; Moreno Torres, Rosario; Llopis, Juan Emilio; Aranda, Pilar; Argüelles Castilla, Sandro; Ayala Gómez, Antonio; Machado Quintana, Alberto; Planells, Elena María (Springer Science + Business Media, 2006)
Critically ill patients suffer from oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS). Although ROS/RNS are constantly produced under normal circumstances, critical illness can ...
Article
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Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition 

Gavilán Dorronzoro, María de la Paz; Pintado Losa, Cristina; Gavilán Dorronzoro, Elena; Jiménez Muñoz, Sebastián; Ríos Sánchez, Rosa María; Vitorica Ferrández, Francisco Javier; Castaño Navarro, Angélica; Ruano Caballero, Diego (Wiley-Blackwell, 2009)
Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome ...
Article
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GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus 

Ruano Caballero, Diego; Araujo, Francisco; Revilla Torres, María Elisa; Vela, Jose; Bergis, Olivier; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology, 2000)
We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric acid, type A (GABAA) receptor (α1, α2, α3, α5, β2, β3, γ2S, and γ2L) and all four subunits of the ...
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Hypothetical pneumocystis jirovecii transmission from immunocompetent carriers to infant response 

Morilla Romero de la Osa, Rubén; Medrano Ortega, Francisco Javier; Varela Aguilar, José Manuel; Horra Padilla, Carmen de la; Respaldiza Salas, Nieves; Calderón Sandubete, Enrique José; Montes Cano, Marco Antonio; Rivero Rivero, Laura; Gutiérrez Rivero, Sonia; Friaza Patiño, Vicente (2009)
Article
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Mitochondrial toxins and neurodegenerative diseases 

Ayala Gómez, Antonio; Venero Recio, José Luis; Cano, Josefina; Machado, Alberto (IMR Press, 2007)
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this ...
Article
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Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging 

Piwien Pilipuk, Graciela; Ayala Gómez, Antonio; Machado de la Quintana, Alberto; Galigniana, Mario D. (American Society for Biochemistry and Molecular Biology, 2002)
Acute and chronic treatments of mice with the gluta- thione-depleting agent, L-buthionine-(SR)-sulfoximine (BSO), impaired the mineralocorticoid receptor (MR)- dependent biological response by inhibiting aldoster- one ...
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