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AuthorArgüelles Castilla, Sandro (2)Camandola, Simonetta (2)Vitorica Ferrández, Francisco Javier (2)Alvarez Vergara, Maria I. (1)Ayala Gómez, Antonio (1)Brown, Charles Guy (1)Burguillos García, Miguel Ángel (1)Carrillo Jiménez, Alejandro (1)Cifuentes, Manuel (1)Claros, Silvia (1)... View MoreSubject14.3.3, p53, lipid peroxidation (1)Alzheimer’s disease (1)Bone marrow-derived mesenchymal stem cells (1)CD33 (1)CRM1 (1)Endurance (1)Eukaryotic elongation factor 2 (eEF-2) (1)hippocampal neurons (1)Hydrocephalus (1)Ischemic stroke (1)... View MoreDate Issued2013 (1)2018 (1)2019 (1)2020 (1)2021 (1)Funding agency
Ministerio de Educación, Cultura y Deporte (MECD). España (5)
Instituto de Salud Carlos III (2)Junta de Andalucía (1)Ministerio de Ciencia e Innovación (MICIN). España (1)Ministerio de Economia, Industria y Competitividad (MINEICO). España (1)Ministerio de Economía y Competitividad (MINECO). España (1)Plan Operativo FEDER Andalucía (1)Universidad de Málaga (1)
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Article
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Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation 

Carrillo Jiménez, Alejandro; Puigdellívol, Mar; Vilalta, Anna; Venero Recio, José Luis; Brown, Charles Guy; Burguillos García, Miguel Ángel (Frontiers Media, 2018)
Microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including Alzheimer’s disease (AD). The use of primary microglial cell cultures has proved to be a ...
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Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress 

Argüelles Castilla, Sandro; Camandola, Simonetta; Hutchison, Emmette R.; Cutler, Roy G.; Ayala Gómez, Antonio (Eslsevier, 2013)
Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA. The activity of eEF-2 is regulated by changes in cellular ...
Article
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Uric acid enhances longevity and endurance and protects the brain against ischemia 

Cutler, Roy G.; Camandola, Simonetta; Feldman, Neil H.; Seon Yoon, Jeong; Haran, James B.; Argüelles Castilla, Sandro; Mattsona, Mark P. (Elsevier, 2019)
Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived ...
Article
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Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells 

García Bonilla, María; García-Martín, María Luisa; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020)
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...
Article
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Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1 

March Diaz, Rosana; Lara Ureña, Nieves; Romero Molina, Carmen; Heras Garvin, Antonio; Ortega de San Luis, Clara; Alvarez Vergara, Maria I.; Navarro Garrido, Victoria; Sánchez Mico, María Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Springer, 2021)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD ...
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