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AuthorVenero Recio, José Luis (7)García Domínguez, Irene (3)García Revilla, Juan (3)Martínez de Pablos, Rocío (3)Pérez Villegas, Eva María (3)Ruiz Laza, Rocío (3)Santiago Pavón, Martiniano (3)Bautista Palomas, Juan Dionisio (2)Boza Serrano, Antonio (2)Carbonero Aguilar, María del Pilar (2)... View MoreSubjectlipopolysaccharide (2)microglia (2)neuroinflammation (2)Parkinson’s disease (2)AbAEE (1)ACUTE TOXICITY (1)AGARICUS BISPOROUS (1)Alzheimer’s disease (AD) (1)AMPK (1)Amyloid aggregation (1)... View MoreDate Issued2018 (4)2020 (3)2015 (2)2016 (1)2019 (1)2021 (1)2022 (1)Funding agency
Ministerio de Economía y Competitividad (MINECO). España (13)
Junta de Andalucía (7)European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) (5)Instituto de Salud Carlos III (5)Universidad de Málaga (2)Centro de Investigaciones Biomédicas en Red (CIBERNED). España (1)Dirección General de Investigación Científica y Técnica (DGICYT). España (1)European Union (UE) (1)Ministerio de Ciencia e Innovación (MICIN). España (1)Ministerio de Educación, Cultura y Deporte (MECD). España (1)... View More
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Article
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RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation 

Buchrieser, Julian; Oliva Martín, María José; Moore, Michael D.; Long, Joshua C. D.; Cowley, Sally A.; Long, Joshua C. D.; Pérez Simón, José Antonio; Venero Recio, José Luis (Springer Nature, 2018)
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory ...
Article
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Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease 

Tayara, Khadija; Espinosa Oliva, Ana María; García Domínguez, Irene; Ismaiel, Afrah Abdul; Boza Serrano, Antonio; Deierborg, Tomas; Martínez de Pablos, Rocío; Machado de la Quintana, Alberto; Herrera Carmona, Antonio José; Venero Recio, José Luis (Frontiers Media, 2018)
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin ...
Article
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Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease 

García Domínguez, Irene; Veselá, Karolina; García Revilla, Juan; Carrillo Jiménez, Alejandro; Roca Ceballos, María Angustias; Santiago Pavón, Martiniano; Martínez de Pablos, Rocío; Venero Recio, José Luis (Frontiers Media, 2018)
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the ...
Article
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Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells 

García Bonilla, María; García-Martín, María Luisa; Ojeda Pérez, Betsaida; Muñoz Hernández, Mª Carmen; Vitorica Ferrández, Francisco Javier; Jiménez Muñoz, Sebastián; Cifuentes, Manuel; Santos Ruíz, Leonor; Shumilov, Kirill; Claros, Silvia; Páez González, Patricia; Jiménez, Antonio J. (BMC, 2020)
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, ...
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study 

Ruiz Laza, Rocío; Pérez Villegas, Eva María; Bachiller, Sara; Rosa, José Luis; Armengol, Jose Ángel (Frontiers Media, 2016)
The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like domain of the HERC1 protein, which leads to the increase of mutated protein levels responsible for ...
Article
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Preliminary Studies of the Toxicity of Agaricus Bisporous Aqueous Enzymatic Extracts (AbAEE) In Rats 

Carbonero Aguilar, María del Pilar; Falcón García, Gonzalo; Gallego Yerga, Paloma; Campo, J.A. del; Moreno Navarro, Isabel María; Bautista Palomas, Juan Dionisio (Avens Publishing Group, 2018)
The health benefits of extracts from Agaricus bisporus greatly extend its use as components of new functional foods for the treatment and prevention of diseases, rather than restricting it to a good food with high nutritional ...
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White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice 

Gallego Yerga, Paloma; Luque Sierra, Amparo; Falcón García, Gonzalo; Carbonero Aguilar, María del Pilar; Grande Santamaría, Lourdes; Bautista Palomas, Juan Dionisio; Martín, Franz (MDPI, 2021)
Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to analyze the effects of a nontoxic, water-soluble extract of the edible mushroom Agaricus bisporus (AB) ...
Article
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HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory 

Pérez Villegas, Eva María; Pérez Rodríguez, Mikel; Negrete Díaz, José V.; Ruiz Laza, Rocío; Rosa, José Luis; Álvarez de Toledo, Guillermo; Rodríguez Moreno, Antonio; Armengol, José Ángel (Frontiers Media, 2020)
Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death ...
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AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin 

Alba Jiménez, Gonzalo; Martínez, Raquel; Postigo Corrales, Fátima; López Enríquez, Soledad; Santa-María Pérez, Consuelo; Jiménez Carrasco, Juan; Cahuana Macedo, Gladys Margot; Soria Escoms, Bernat; Bedoya Bergua, Francisco Javier; Tejedo Huamán, Juan Rigoberto (American Chemical Society, 2020)
Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. Though the gene regulatory mechanism for pluripotency has been investigated in recent years, it ...
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Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model 

Kavanagh, Edel T.; Burguillos García, Miguel Ángel; Carrillo Jiménez, Alejandro; Oliva Martín, María José; Santiago Pavón, Martiniano; Rodhe, Johanna; Joseph, Bertrand; Venero Recio, José Luis (Impact Journals, LLC, 2015)
Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and ...
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