Listar Artículos (Bioquímica y Biología Molecular) por agencia financiadora "Ministerio de Ciencia e Innovación (MICIN). España"
Mostrando ítems 1-20 de 30
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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
(Public Library of Science, 2017)Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
(Springer Nature, 2022)ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and ...
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Application of a Protein Hydrolysate-Based Biostimulant Obtained from Slaughterhouse Sludge on Pepper Crops
(MDPI, 2023-10-01)Currently, biostimulants obtained from protein hydrolysates are considered essential agronomic tools to promote sustainable ...
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ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
(Nature Research, 2023)Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ...
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Assessment of the oxidative status in mother-child couples from Seville (Spain): A prospective cohort study
(Elsevier, 2023-10)Pregnancy requires a high demand of energy, which leads to an increase of oxidative stress. The aim of this study was to ...
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Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
(BMC, 2022)Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...
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Biochemical and Microbiological Soil Effects of a Biostimulant Based on Bacillus licheniformis-Fermented Sludge
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Biostimulants are substances and/or microorganisms that are applied to plants or to the rhizosphere in order to enhance ...
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Biomethane production improvement by enzymatic pre-treatments and enhancers of sewage sludge anaerobic digestion
(Elsevier, 2019)Enzymatic hydrolysis is recognised as an effective pre-treatment for increasing biodegradability of sludge. In this work, ...
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CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance
(Frontiers Media S.A., 2017-02-10)Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an ...
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Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions
(Elsevier, 2013)Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) ...
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Enzymatic Preparation of Mushroom By-product Protein Hydrolysates (Mb-PPHs)
(Springer, 2023-08-14)The excessive use of chemical fertilizers can cause severe environmental damage. In recent decades, the application of ...
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Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth
(Elsevier, 2024-04-16)Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various ...
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Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
(Springer, 2022)Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous ...
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Galectin-3 is upregulated in frontotemporal dementia patients with subtype specificity
(Wiley, 2023-11)INTRODUCTION Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 ...
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Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease.
(Springer, 2023)Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions ...
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study
(Frontiers Media, 2016)The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like ...
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How the Local Geometry of the Cu-Binding Site Determines the Thermal Stability of Blue Copper Proteins
(Elsevier, 2011-01)Identifying the factors that govern the thermal resistance of cupredoxins is essential for understanding their folding and ...
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In vitro and in Vivo Protection by Melatonin Against the Decline of Elongation Factor-2 Caused by Lipid Peroxidation: Preservation of Protein Synthesis
(Wiley-Blackwell, 2012)As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of ...
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Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry
(Elsevier, 2015-01-05)The identification of pathological mechanisms underlying to Alzheimer's disease is of great importance for the discovery ...
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Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality
(Nature, 2024-07-24)Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related ...