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Tesis Doctoral
Patente
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Procedimiento de obtención de extractos enzimáticos con actividad farmacológica a partir de orujo de uva
(Oficina Española de Patentes y Marcas , 2014-09-01)
El objeto de la invención es el desarrollo de un nuevo proceso biológico de extracción que conduzca a la obtención de un extracto con actividad farmacológica a partir de orujo de uva.El proceso conduce a la obtención de ...
Artículo
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Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
(American Society for Biochemistry and Molecular Biology Inc., 2011)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ...
Artículo
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Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
(Springer Nature, 2021)
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase ...
Artículo
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GABAa and a-Amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus
(American Society for Biochemistry and Molecular Biology, 2000)
We have investigated the age-dependent modifications in the expression of eight different subunits of the γ-aminobutyric acid, type A (GABAA) receptor (α1, α2, α3, α5, β2, β3, γ2S, and γ2L) and all four subunits of the ...
Tesis Doctoral
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Metformin treatment decreases microglial activation in the in vivo lps model of parkinson's disease.
(2018-11-23)
Metformin is a widely used oral antidiabetic drug with known anti-inflammatory properties due to its action on AMP kinase. This drug has shown a protective effect on various brain tissues, including cortical neurons. ...
Artículo
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Reformulating Pro-Oxidant Microglia in Neurodegeneration
(MDPI, 2019)
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered ...
Artículo
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Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-12)
Nemaline myopathy (NM) is one of the most common forms of congenital myopathy and it is identified by the presence of “nemaline bodies” (rods) in muscle fibers by histopathological examination. The most common forms of NM ...
Artículo
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Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus
(Elsevier, 2016)
The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and neurodegenerative diseases are poorly understood. The main objective of this study was to test the effect ...
Artículo
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Update on modifiable risk factors for Alzheimer’s disease and related dementias
(Wolters Kluwer, 2024)
Purpose of review. All human beings undergo a lifelong cumulative exposure to potentially preventable adverse factors such as toxins, infections, traumatisms, and cardiovascular risk factors, collectively termed exposome. ...