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Listar Artículos (Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja) por autor "García Fernández, José Manuel"
Mostrando ítems 21-40 de 41
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Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017)Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
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Artículo
Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies
Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013)Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ...
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Novel Therapies for Orphan Diseases
García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)"Orphan" does not mean infrequent: over 7000 rare diseases affect millions of individuals. The US Orphan Drug Act and ...
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Pharmacological chaperone therapy for Gaucher disease: A patent review
Benito, Juan Manuel; García Fernández, José Manuel; Ortiz Mellet, Carmen (Taylor & Francis, 2011)Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher ...
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Pharmacological Chaperones for the Treatment of α-Mannosidosis
Rísquez Cuadro, Rocío; Matsumoto, Reimi; Ortega Caballero, Fernando; Nanba, Eiji; Higaki, Katsumi; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2019)α-Mannosidosis (AM) results from deficient lysosomal α-mannosidase (LAMAN) activity and subsequent substrate accumulation ...
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Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human -Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease
Mena Barragán, Teresa; García Moreno, M. Isabel; Sevšek, Alen; Okazaki, Tetsuya; Nanba, Eiji; Higaki, Katsumi; Martin, Nathaniel I.; Pieteres, Roland J.; García Fernández, José Manuel; Ortiz Mellet, Carmen (Molecular Diversity Preservation International, 2018)A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern ...
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Self-association of a naphthalene-capped-β-cyclodextrin through cooperative strong hydrophobic interactions
González-Álvarez, M.José; Méndez Ardoy, Alejandro; Benito Hernández, Juan Manuel; García Fernández, José Manuel; Mendicuti, Francisco (Elsevier, 2011-09-05)NMR, circular dichroism and fluorescence techniques were used to study the structure in solution of a new β-cyclodextrin ...
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Serine-/Cysteine-based sp2-Iminoglycolipids as novel TLR4 agonists: evaluation of their adjuvancy and immunotherapeutic properties in a murine model of asthma
González Cuesta, Manuel; Lai, Alan Chuan Ying; Chi, Po Yu; Hsu, I. Ling; Liu, Nien Tzu; Wu, Ko Chien; García Fernández, José Manuel; Ortiz Mellet, Carmen (American Chemical Society, 2023)Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating ...
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sp2-Iminosugar Glycolipids as Inhibitors of Lipopolysaccharide-mediated Human Dendritic Cell Activation in Vitro and of Acute Inflammation in Mice in Vivo
Schaeffer, Evelyne; Sánchez Fernández, Elena Matilde; Gonçalves-Pereira, Rita; Flacher, Vincent; Lamon, Delphine; Duval, Monique; Fauny, Jean Daniel; García Fernández, José Manuel; Mueller, Christopher G.; Ortiz Mellet, Carmen (Elsevier, 2019)Glycolipid mimetics consisting of a bicyclic polyhydroxypiperidine-cyclic carbamate core and a pseudoanomeric hydrophobic ...
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sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
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Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process
Cano, María Emilia; Varela, Oscar; García Moreno, M. Isabel; García Fernández, José Manuel; Kovensky, José; Uhrig, María Laura (Elsevier, 2017)The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
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Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process
Cano, María Emilia; Varela, Oscar; García Moreno, M. Isabel; García Fernández, José Manuel; Kovensky, José; Uhrig, María Laura (Elsevier, 2017)The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived ...
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Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo
Aranda, Cristina; Urbiola, Koldo; Méndez Ardoy, Alejandro; García Fernández, José Manuel; Ortiz Mellet, Carmen; Ilarduya, C.T. (Elsevier, 2013)Aim Development and evaluation of a new targeted gene delivery system by first preforming self-assembled nanocomplexes ...
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The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study
García Moreno, M. Isabel; Ortega Caballero, Fernando; Rísquez Cuadro, Rocio; García Fernández, José Manuel; Ortiz Mellet, Carmen (2017)The vision of multivalency as a strategy limited to achieve affinity enhancements between a protein receptor and its ...
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Toward a Suitable Structural Analysis of Gene Delivery Carrier Based on Polycationic Carbohydrates by Electron Transfer Dissociation Tandem Mass Spectrometry
Przybylski, Cédric; Benito, Juan Manuel; Bonnet, Véronique; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2016)Polycationic carbohydrates represent an attractive class of biomolecules for several applications and particularly as non ...
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Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators
Rodríguez Lavado, Julio; Sestito, Stefania E.; Cighetti, Roberto; Aguilar Moncayo, Eva M.; Oblak, Alja; Lainšček, Duško; Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Jerala, Roman; Calabrese, Valentina; Peri, Francesco (American Chemical Society, 2014)An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ...
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Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles
Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Blanco Fernández, L.; Carmona, Thais; Marcelo, G.; Martínez Negro, María; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016)The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ...
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
Carbajo Gordillo, Ana Isabel; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019-06-19)An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ...
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Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
Ortega Caballero, Fernando; Santana Armas, Maria L.; Tros de Ilarduya, Conchita; Di Giorgio, Christophe; Tripier, Raphael; Le Bris, Nathalie; Ollier, Cedric; Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis; Méndez Ardoy, Alejandro (Royal Society of Chemistry, 2024-03-05)A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ...
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Unprecedented Inhibition of Glycosidase-Catalyzed Substrate Hydrolysis by Nanodiamond-Grafted O-Glycosides
Siriwardena, A.; Khanal, M.; Barras, Alexandre; Bande, O.; Mena Barragán, Teresa; Ortiz Mellet, Carmen; García Fernández, José Manuel; Boukheroub, R.; Szunerits, S. (Royal Society of Chemistry, 2015)We report herein the unprecedented finding that α-O-glucosides and also α-O-mannosides, when conjugated on nanodiamond ...