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Browsing Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja by Author "Herrera González, Irene"
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Article
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
González Cuesta, Manuel; Herrera González, Irene; García Moreno, M. Isabel; Ashmus, Roger A.; Vocadlo, David J.; García Fernández, José Manuel; Nanba, Eiji; Higaki, Katsumi; Ortiz Mellet, Carmen (Taylor & Francis, 2022)The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below ...
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Article
Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis
Herrera González, Irene; Sánchez Fernández, Elena Matilde; Sau, Abhijit; Nativi, Cristina; Garciá Fernández, José M.; Galán, M. Carmen; Ortiz Mellet, Carmen (American Chemical Society, 2020)The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ...