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Mostrando ítems 11-20 de 30
Artículo
Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding
(Nature Research, 2009)
The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1). In the cell, ...
Artículo
Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength
(Elsevier, 2015)
The transient interactions of respiratory cytochrome c with complexes III and IV is herein investigated by using heterologous proteins, namely human cytochrome c, the soluble domain of plant cytochrome c1 and bovine ...
Artículo
NMR analysis of the transient complex between membrane photosystem I and soluble cytochrome c6
(Elsevier, 2005)
A structural analysis of the surface areas of cytochrome c6, responsible for the transient interaction with photosystem I, was performed by NMR transverse relaxation-optimized spectroscopy. The hemeprotein was titrated by ...
Artículo
Structural and Functional Analysis of Novel Human Cytochrome c Targets in Apoptosis
(American Society for Biochemistry and Molecular Biology, 2014)
Since the first description of apoptosis four decades ago, great efforts have been made to elucidate, both in vivo and in vitro, the molecular mechanisms involved in its regulation. Although the role of cytochrome c during ...
Artículo
Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c
(National Academy of Sciences, 2015)
Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA repair docking site. Recent works identify histone chaperones as key regulators of damaged chromatin’s ...
Artículo
The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
(Taylor & Francis, 2014)
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal and central domains (RRM1 and RRM2) are essential ...
Artículo
New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants
(American Society for Biochemistry and Molecular Biology, 2013)
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, programmed cell death is necessary for development and the hypersensitive response to stress or pathogenic ...
Artículo
Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin
(American Society for Biochemistry and Molecular Biology, 2013)
Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface ...
Artículo
Molecular basis of FIR-mediated c-myc transcriptional control
(Nature Research, 2010)
The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream of the c-myc promoter. Then, ...
Artículo
A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein
(Elsevier, 2011)
T-cell intracellular antigen-1 (TIA-1) plays a pleiotropic role in cell homeostasis through the regulation of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs. TIA-1 contains ...