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Tesis Doctoral
Artículo
Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence
(Biomed Central, 2018-11-15)
Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the last decades and is considered an important driver for the rapid increase of quinolone resistance ...
Artículo
Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments
(MDPI, 2018)
Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane ...
Artículo
Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain
(Springer, 2018)
Introduction Clostridium difficile infection (CDI) is the major cause of infectious nosocomial diarrhoea and is associated with considerable morbidity, mortality and economic impact. Bezlotoxumab administered in combination ...
Artículo
Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii
(Taylor & Francis, 2018)
Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used ...
Artículo
Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
(MDPI, 2018)
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein ...
Artículo
Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
(Elsevier, 2018)
Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection (BUTI). The analysis identified optimal regimens on the basis of pharmacodynamic targets and ...
Tesis Doctoral
Effect of urinary tract physiological conditions on quinolones and fosfomycin activity against Escherichia coli
(2018-06-28)
Las infecciones del trato urinario (ITUs) constituyen una de las infecciones bacterianas más frecuentes tanto a nivel comunitario como hospitalario. Durante los últimos años se ha descrito un aumento en las tasas de ...
Artículo
Duration of Colonization by Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: a Prospective Cohort Study
(Oxford University Press, 2018)
Duration of colonization by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated with it were studied in 20 newborns in Seville, Spain. Median duration of colonization was 7.5 months; ...
Artículo
Transcriptomic studies of the effect of nod gene-inducing molecules in rhizobia: Different weapons, one purpose
(Multidisciplinary Digital Publishing Institute (MDPI), 2018)
Simultaneous quantification of transcripts of the whole bacterial genome allows the analysis of the global transcriptional response under changing conditions. RNA-seq and microarrays are the most used techniques to measure ...