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Impact of De-escalation on Prognosis of Patients With Bacteremia due to Enterobacteriaceae: A Post Hoc Analysis From a Multicenter Prospective Cohort
(Oxford University Press, 2019)
Background More data are needed about the safety of antibiotic de-escalation in specific clinical situations as a strategy to reduce exposure to broad-spectrum antibiotics. The aims of this study were to investigate ...
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Activity of Host Antimicrobials against Multidrug-Resistant Acinetobacter baumannii Acquiring Colistin Resistance through Loss of Lipopolysaccharide
(American Society for Microbiology, 2014-05)
Acinetobacter baumannii can acquire resistance to the cationic peptide antibiotic colistin through complete loss of lipopolysaccharide (LPS) expression. The activities of the host cationic antimicrobials LL-37 and human ...
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A novel stabilization mechanism for the type VI secretion system sheath
(National Academy of Sciences, 2021)
The type VI secretion system (T6SS) is a phage-derived contractile nanomachine primarily involved in interbacterial competition. Its pivotal component, TssA, is indispensable for the assembly of the T6SS sheath structure, ...
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Prevalence and risk factors for multidrug-resistant organisms colonization in long-term care facilities around the world: a review
(MDPI, 2021-06-07)
Elderly people confined to chronic care facilities face an increased risk of acquiring infections by multidrug-resistant organisms (MDROs). This review presents the current knowledge of the prevalence and risk factors for ...
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Study protocol for a randomized clinical trial to assess 7 versus 14-days of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial)
(2022-12-22)
Background Research priorities in Antimicrobial Stewardship (AMS) have rapidly evolved in the last decade. The need for a more efficient use of antimicrobials have fueled plenty of studies to define the optimal duration ...
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Long-Term Impact of an Educational Antimicrobial Stewardship Program on Management of Patients with Hematological Diseases
(MDPI, 2021)
Antimicrobial stewardship programs (ASPs) in hematological patients are especially relevant. However, information about ASPs in this population is scarce. For 11 years, we quarterly assessed antimicrobial consumption and ...
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Antimicrobial Stewardship in the Emergency Department Observation Unit: Definition of a New Indicator and Evaluation of Antimicrobial Use and Clinical Outcomes
(MDPI, 2024-04-12)
We aimed to define a novel indicator for monitoring antimicrobial use specifically in the Emergency Department Observation Unit (EDOU) and to assess the long-term impact of an institutional education-based antimicrobial ...
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The global threat of antimicrobial resistance: science for intervention
(2015)
In the last decade we have witnessed a dramatic increase in the proportion and absolute number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant bacteria are currently considered as an ...
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Characterization of a clinical isolate of Haemophilus influenzae with a high level of fluoroquinolone resistance
(Oxford University Press, 2006-01-23)
Haemophilus influenzae is one of the bacterial pathogens most likely to be involved in community-acquired respiratory infections in patients with chronic obstructive pulmonary disease. In this species, resistance to ...
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Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli
(Oxford University Press, 2020)
Objectives: To explore the effect of combining defects in DNA repair systems with the presence of fosfomycin-resistant mechanisms to explain the mechanisms underlying fosfomycin heteroresistance phenotypes in Enterobacte ...