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Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
(Wiley-Blackwell, 2023-02-14)
Pseudomonas aeruginosa (PA) is an opportunistic human pathogen, which is involved in a wide range of dangerous infections. It develops alarming resistances toward antibiotic treatment. Therefore, alternative strategies, ...
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Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
(American Society for Microbiology, 1998-07-01)
The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation ...
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A pyrF auxotrophic mutant of Sinorhizobium fredii HH103 impaired in its symbiotic interaction with soybean and other legumes
(Sociedad Española de Microbiología. Viguera Editores, 2007)
Transposon Tn5-Mob mutagenesis allowed the selection of a Sinorhizobium fredii HH103 mutant derivative (SVQ 292) that requires the presence of uracil to grow in minimal media. The mutated gene, pyrF, codes for an ...
PhD Thesis
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El ciclo celular y procesos cariológicos relacionados con la regeneración en laurentia acuminata
(1977-09-01)
La división celular es un proceso complejo, mediante el cual a partir de una célula se originan dos células hijas que, en la mayoría de los casos, son idénticas entre sí e idénticas a la célula de donde proceden. Este ...
PhD Thesis
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Estudios genéticos y fisiológicos del gen regulador nodD de Rhizobium fredii ii HH103
(1997-06-16)
En nuestro laboratorio trabajamos con diversas estirpes de Rhizobium fredii. En el trabajo que se presenta a continuación se ha realizado un estudio de la regulación de los genes de nodulación de la estirpe HH103 de Rhizobium ...
Article
PhD Thesis
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Activity of imipenem/relebactam and comparators against KPC-producing Klebsiella pneumoniae and imipenem-resistant Pseudomonas aeruginosa
(Springer, 2023-12-29)
Purpose: Relebactam is a novel β-lactamase inhibitor, which, when combined with imipenem/cilastatin, is active against both class A and class C β-lactamases. To evaluate in vitro antimicrobial activity of imipenem/relebactam ...
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Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa
(American Society for Microbiology, 2003-07-01)
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is ...
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Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances
(MDPI, 2021)
The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those ...