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Mostrando ítems 1-5 de 5
Artículo
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
(Frontiers Media, 2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle ...
Artículo
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its ...
Artículo
The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
(Frontiers Media S.A., 2021)
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated ...
Artículo
Therapeutic Opportunities of Disrupting Genome Integrity inAdult Diffuse Glioma
(MDPI, 2022)
Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present ...
Artículo
MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair
(Wiley-Blackwell, 2021)
The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing ...