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DNA adenine methylase mutants of Salmonella typhimurium show defects in protein secretion, cell invasion, and M cell cytotoxicity
(National Academy of Sciences, 1999)
Mutants of Salmonella typhimurium lacking DNA adenine methylase are attenuated for virulence in BALB/c mice. LD50 values of a DNA adenine methylation (Dam)- mutant are at least 103- to 104-fold higher than those of the ...