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Mostrando ítems 1-6 de 6
Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed ...
Artículo
A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
(Oxford University Press, 2014)
The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking transcription elongation with mRNA export and genome stability, as shown for specific reporters. ...
Artículo
Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery
(Rockefeller University Press, 2009)
The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in mammalian cells, binds the tumor suppressor protein BRCA2. Here, we describe a new function for yeast ...
Artículo
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One important player in this interface is the poly(A) + -RNA– binding protein Nab2, which ...
Artículo
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
(American Society for Cell Biology, 2008)
The eukaryotic THO/TREX complex, involved in mRNP biogenesis, plays a key role in the maintenance of genome integrity in yeast. mRNA export factors such as Thp1-Sac3 also affect genome integrity, but their mutations have ...
Artículo
New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation
(American Society for Microbiology, 2011)
Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA processing and RNA export. A key link between these processes is provided by the THO complex. To progress ...