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Artículo
DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
(Frontiers Media, 2019)
DNA double strand breaks (DSBs) are the most cytotoxic lesions of those occurring in the DNA and can lead to cell death or result in genome mutagenesis and chromosomal translocations. Although most of these rearrangements ...
Artículo
Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1
(National Academy of Sciences, 2011)
Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform NER initial steps but not late steps of postincision gap filing. Because removal of early-acting NER ...
Artículo
The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
(Cold Spring Harbor Laboratory Press, 2014)
FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA polymerase during transcription elongation and has a role in replication that is not fully understood ...
Artículo
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
(Elsevier, 2014)
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also ...