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Artículo
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent R-loop accumulation. One mechanism relies on the conserved THO complex in association with cotranscriptional ...
Artículo
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent ...
Artículo
The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
(Cold Spring Harbor Laboratory Press, 2014)
FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA polymerase during transcription elongation and has a role in replication that is not fully understood ...
Artículo
The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability
(Cold Spring Harbor Laboratory Press, 2013)
Transcription is a major obstacle for replication fork (RF) progression and a cause of genome instability. Part of this instability is mediated by cotranscriptional R loops, which are believed to increase by suboptimal ...