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Mostrando ítems 1-10 de 14
Artículo
Patterns of expression and translocation of the ubiquitin ligase SlrP in Salmonella enterica serovar typhimurium.
(American Society for Microbiology, 2014)
SlrP is an E3 ubiquitin ligase that can be translocated into eukaryotic host cells by the two type III secretion systems that are expressed by Salmonella enterica serovar Typhimurium and are encoded in Salmonella pathogenicity ...
Artículo
A Live Salmonella Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosa
(American Society for Microbiology, 2019)
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against P. aeruginosa remains a major ...
Artículo
Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1
(MDPI, 2020)
Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to manipulate the host cell and fulfill infection. SseK1 is a Salmonella effector with glycosyltransferase ...
Artículo
Molecular Mechanisms Used by Salmonella to Evade the Immune System
(Caister Academic Press, 2018)
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for ...
Artículo
SrfJ, a salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.
(American Society for Microbiology, 2012)
Virulence-related type III secretion systems are present in many Gram-negative bacterial pathogens. These complex devices translocate proteins, called effectors, from the bacterium into the eukaryotic host cell. Here, we ...
Artículo
The salmonella type III secretion effector, Salmonella Leucine-rich Repeat Protein (SlrP), targets the human chaperone ERdj3
(Elsevier, 2010)
Effectors of the type III secretion systems (T3SS) are key elements in the interaction between many Gram-negative pathogens and their hosts. SlrP is an effector that is translocated into the eukaryotic host cell through ...
Artículo
Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity
(MDPI, 2020)
Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal ...
Artículo
The Structure of the SlrP-hTrx1 Complex Sheds Light on the Autoinhibition Mechanism of the Type-III Secretion System Effectors of the NEL Family
(Portland Press, 2014-11-15)
Salmonella infections are a leading cause of bacterial foodborne illness in the United States and the European Union. Antimicrobial therapy is often administered to treat the infection but increasing isolates are being ...
Artículo
Global impact of Salmonella type III secretion effector SteA on host cells
(Elsevier, 2014-07-11)
Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems, ...
Artículo
Proteomic insight into the effects of the Salmonella ubiquitin ligase SlrP on host cells
(Elsevier, 2016)
The virulence of the human and animal pathogen Salmonella enterica serovar Typhimurium is dependent on two type III secretion systems. These systems translocate proteins called effectors into eukaryotic host cells. SlrP ...