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Artículo
Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts
(Frontiers Media, 2017)
Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the ...
Artículo
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF
(Oxford Academic, 2019-09-05)
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon ...
Artículo
LeuO is a global regulator of gene expression in Salmonella enterica serovar Typhimurium
(Wiley-Blackwell, 2012)
We report the first investigation of the binding of the Salmonella enterica LeuO LysR-type transcription regulator to its genomic targets in vivo. Chromatin-immunoprecipitation-on-chip identified 178 LeuO binding sites on ...
Artículo
Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica
(Oxford University Press, 2020)
Expression of Salmonella enterica loci harboring undermethylated GATC sites at promoters or regulatory regions was monitored by single cell analysis. Cell-to-cell differences in expression were detected in ten such loci ...
Artículo
Mutational and non mutational adaptation of Salmonella enterica to the gall bladder
(Natural Research, 2019)
During systemic infection of susceptible hosts, Salmonella enterica colonizes the gall bladder, which contains lethal concentrations of bile salts. Recovery of Salmonella cells from the gall bladder of infected mice yields ...
Artículo
Identification of the Salmonella enterica damX gene product, an inner membrane protein involved in bile resistance
(American Society for Microbiology, 2010)
The damX gene product of Salmonella enterica serovar Typhimurium is a protein located in the inner membrane. DamX migrates as a 70-kDa protein in SDS-PAGE even though the predicted protein size is 46 kDa. Synthesis of DamX ...
Artículo
Artículo
Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella
(National Academy of Sciences, 2015)
Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria. Although ...
Artículo
OxyR-dependent formation of DNA methylation patterns in OpvABOFF and OpvABON cell lineages of Salmonella enterica
(Oxford University Press, 2015)
Phase variation of the Salmonella enterica opvAB operon generates a bacterial lineage with standard lipopolysaccharide structure (OpvABOFF) and a lineage with shorter O-antigen chains (OpvABON). Regulation of OpvAB lineage ...
Artículo
Dormant intracellular salmonella enterica serovar typhimurium discriminates among salmonella pathogenicity island 2 effectors to persist inside fibroblasts
(American Society for Microbiology, 2014-01)
Salmonella enterica uses effector proteins delivered by type III secretion systems (TTSS) to colonize eukaryotic cells. Recent in vivo studies have shown that intracellular bacteria activate the TTSS encoded by Salmonella ...