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Artículo
R Loops: From Physiologicalto Pathological Roles
(Elsevier, 2019-10-17)
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating ...
Artículo
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
(Elsevier, 2014)
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also ...