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Artículo
The Cell Wall Integrity Pathway Contributes to the Early Stages of Aspergillus Fumigatus Asexual Development
(American Society for Microbiology, 2020)
Aspergillus fumigatus is a major cause of human disease. The survival of this fungus is dependent on the cell wall organization and function of its components. The cell wall integrity pathway (CWIP) is the primary signaling ...
Artículo
Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer
(2020-04-24)
Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) ...
Artículo
Prefoldin-like Bud27 influences the transcription of ribosomal components and ribosome biogenesis in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2020)
Understanding the functional connection that occurs for the three nuclear RNA polymerases to synthesize ribosome components during the ribosome biogenesis process has been the focal point of extensive research. To preserve ...
Artículo
Fungal Secondary Metabolism
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Definition: Fungal secondary metabolites (SMs) comprise a vast collection of compounds expendable for these organisms under laboratory conditions. They exhibit enormous chemical diversity, and usu- ally belong to four ...
Artículo
The Total mRNA Concentration Buffering System in Yeast is Global Rather than Gene-specific
(Cold Spring Harbor Laboratory Press, 2021)
Gene expression in eukaryotes does not follow a linear process from transcription to translation and mRNA degradation. Instead it follows a circular process in which cytoplasmic mRNA decay crosstalks with nuclear transcription. ...
Artículo
PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
(MDPI, 2020)
Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer is preoperative radiation alone or in combination with chemotherapy, followed by adjuvant chemotherapy. ...
Artículo
Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
(Frontiers Media S.A., 2021)
Eukaryotic life is possible due to the multitude of complex and precise phenomena that take place in the cell. Essential processes like gene transcription, mRNA translation, cell growth, and proliferation, or membrane ...
Artículo
The role of chromatin at transcription-replication conflicts as a genome safeguard
(Portland Press, 2021)
DNA replication ensures the correct copying of the genome and the faithful transfer of the genetic information to the offspring. However, obstacles to replication fork (RF) progression cause RF stalling and compromise ...
Artículo
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
(Nature Publishing Group, 2021)
The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA lesions. RNA editing, the post-transcriptional sequence alteration of RNA, has a profound effect on cell ...
Artículo
Controlled Transcription of Regulator Gene carS by Tet-on or by a Strong Promoter Confirms Its Role as a Repressor of Carotenoid Biosynthesis in Fusarium fujikuroi
(MDPI, 2020-12)
Carotenoid biosynthesis is a frequent trait in fungi. In the ascomycete Fusarium fujikuroi, the synthesis of the carboxylic xanthophyll neurosporaxanthin (NX) is stimulated by light. However, the mutants of the carS gene, ...