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Mostrando ítems 81-90 de 461
Artículo
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
(Springer Nature, 2019)
In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, ...
Artículo
Yeast ribosomal protein L40 assembles late into precursor 60 S ribosomes and is required for their cytoplasmic maturation
(Elsevier, 2012)
Background: The contribution of ribosomal proteins to ribosome assembly and function is often not well understood. Results: L40 assembles within the cytoplasm into pre-60 S subunits and is required for Nmd3 and Rlp24 ...
Artículo
Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
(2016)
It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of ...
Artículo
Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu–Sir4 interaction
(Oxford University Press, 2017)
Ultraviolet light (UV) causes DNA damage that is removed by nucleotide excision repair (NER). UVinduced DNA lesions must be recognized and repaired in nucleosomal DNA, higher order structures of chromatin and within ...
Artículo
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
(Cold Spring Harbor Laboratory Press, 2020)
Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent R-loop accumulation. One mechanism relies on the conserved THO complex in association with cotranscriptional ...
Artículo
Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?
(Frontiers Media S.A., 2022)
Artículo
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
(Elsevier, 2021)
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. ...
Artículo
Genome-wide studies of mRNA synthesis and degradation in eukaryotes
(Elsevier BV, 2012)
In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life. The statistical analyses of the results for ...
Artículo
Surface modulation of single-walled carbon nanotubes for selective bacterial cell agglutination
(Dove Medical Press, 2019)
Background: Bacterial resistance to antibiotics is one of the biggest challenges facing medicine today. Anti-adhesive therapy, using inhibitors of bacterial adhesion to epithelial cells, one of the first stages of ...
Artículo
Molecular Mechanisms Used by Salmonella to Evade the Immune System
(Caister Academic Press, 2018)
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for ...