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Artículo
Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica
(Oxford University Press, 2020)
Expression of Salmonella enterica loci harboring undermethylated GATC sites at promoters or regulatory regions was monitored by single cell analysis. Cell-to-cell differences in expression were detected in ten such loci ...
Artículo
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
(Elsevier, 2020)
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 ...
Artículo
Regulation of igaA and the rcs system by the mvia response regulator in salmonella enterica
(American Society for Microbiology, 2009)
IgaA is a membrane protein that prevents overactivation of the Rcs regulatory system in enteric bacteria. Here we provide evidence that igaA is the first gene in a 70-dependent operon of Salmonella enterica serovar Typhimurium ...
Artículo
Mutational and non mutational adaptation of Salmonella enterica to the gall bladder
(Natural Research, 2019)
During systemic infection of susceptible hosts, Salmonella enterica colonizes the gall bladder, which contains lethal concentrations of bile salts. Recovery of Salmonella cells from the gall bladder of infected mice yields ...
Artículo
Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.
(Nature Research, 2023)
Bacterial biofilms are surface-attached communities that are difficult to eradicate due to a high tolerance to antimicrobial agents. The use of non-biocidal surface-active compounds to prevent the initial adhesion and ...
Artículo
The Role of Replication-Associated Repair Factors on R-Loops
(MDPI, 2017)
The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication ...
Artículo
IS200: an old and still bacterial transposon
(Springer Verlag, 2004)
IS200 is a mobile element found in a variety of eubacterial genera, such as Salmonella, Escherichia, Shigella, Vibrio, Enterococcus, Clostridium, Helicobacter, and Actinobacillus. In addition, IS200-like elements are found ...
Artículo
Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
(Oxford University Press, 2007)
Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, but a study of repair of DSBs specifically induced during S-phase is lacking. Using an inverted-repeat ...
Artículo
Threonine overproduction in yeast strains carrying the HOM3-R2 mutant allele under the control of different inducible promoters
(American Society for Microbiology, 1999)
The HOM3 gene of Saccharomyces cerevisiae codes for aspartate kinase, which plays a crucial role in the regulation of the metabolic flux that leads to threonine biosynthesis. With the aim of obtaining yeast ...
Artículo
Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Understanding which intracellular signaling pathways are activated by manganese stress is crucial to decipher how metal overload compromise cellular integrity. Here, we unveil a role for oxidative and cell wall stress ...