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Mostrando ítems 451-460 de 461
Artículo
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
(Wiley-Blackwell, 2021)
The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. BRCA2-deficient cells spontaneously accumulate DNA-RNA hybrids, a known source of genome instability. ...
Artículo
Oils and fats on food: is it possible to have a healthy diet?
(CSIC, 2017)
Oils and fats are an important part of our diet as components of many food formulations. Thus, they are retailed for domestic or hostelry uses and broadly used by food industry for the elaboration of margarines, ice ...
Artículo
RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
(Cold Spring Harbor Laboratory Press, 2024-07)
Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously ...
Artículo
Heterogeneity of DNA damage incidence and repair in different chromatin contexts
(Elsevier, 2021)
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its ...
Artículo
Limited ER quality control for GPI-anchored proteins
(Rockefeller University Press, 2016)
Endoplasmic reticulum (ER) quality control mechanisms target terminally misfolded proteins for ER-associated degradation (ERAD). Misfolded glycophosphatidylinositol-anchored proteins (GPI-APs) are, however, generally poor ...
Artículo
Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales
(Nature Research, 2024-07-18)
DNA N6-adenine methylation (6mA) has recently gained importance as an epigenetic modification in eukaryotes. Its function in lineages with high levels, such as early-diverging fungi (EDF), is of particular interest. Here, ...
Artículo
The RNAi Machinery in the Fungus Fusarium fujikuroi Is Not Very Active in Synthetic Medium and Is Related to Transposable Elements
(Multidisciplinary Digital Publishing Institute (MDPI), 2024-05-16)
Small RNAS (sRNAs) participate in regulatory RNA interference (RNAi) mechanisms in a wide range of eukaryotic organisms, including fungi. The fungus Fusarium fujikuroi, a model for the study of secondary metabolism, contains ...
Artículo
EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
(Oxford University Press, 2024-06-24)
DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to the accumulation of single-stranded DNA (ssDNA) that triggers the activation of the ATR checkpoint ...
Artículo
Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation
(MDPI, 2022)
Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral organs. Although mesothelial cells are phenotypically well characterized, their immunoregulatory ...
Artículo
Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast
(Elsevier, 2023-06)
Transcription in Saccharomyces cerevisiae is associated with elevated mutation and this partially reflects enhanced damage of the corresponding DNA. Spontaneous deamination of cytosine to uracil leads to CG>TA mutations ...