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Mostrando ítems 181-190 de 452
Artículo
Evidence for an arginine-dependent route for the synthesis of NO in the model filamentous fungus Aspergillus nidulans
(Wiley-Blackwell, 2021)
Nitric oxide (NO) is a signalling molecule in eukaryotic and prokaryotic organisms. NO levels transiently boost upon induction of conidiation in Aspergillus nidulans. Only one pathway for NO synthesis involving nitrate ...
Artículo
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress
(American Society for Cell Biology, 2009)
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to osmostress activates the Hog1 SAPK, which modulates cell cycle ...
Artículo
The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
(Cold Spring Harbor Laboratory Press, 2014)
FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA polymerase during transcription elongation and has a role in replication that is not fully understood ...
Artículo
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
(Wiley-Blackwell, 2018)
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) ...
Artículo
Redox controls reca protein activity via reversible oxidation of its methionine residues
(eLife Sciences Publications, 2021)
Reactive oxygen species (ROS) cause damage to DNA and proteins. Here we report that the RecA recombinase is itself oxidized by ROS. Genetic and biochemical analyses revealed that oxidation of RecA altered its DNA repair ...
Artículo
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution of mRNP biogenesis and export in transcription-coupled repair (TCR). Interestingly, mutants of THO, ...
Artículo
TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
(Public Library of Science, 2020)
TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). ...
Artículo
CtIP-mediated Alternative mRNA Splicing Fine-tunes the DNA Damage Response
(Cold Spring Harbor Laboratory Press, 2021)
In order to survive to the exposure of DNA damaging agents, cells activate a complex response that coordinates the cellular metabolism, cell cycle progression, and DNA repair. Among many other events, recent evidence has ...
Artículo
Asymmetric cell division requires specific mechanisms for adjusting global transcription
(Oxford University Press, 2017)
Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division ...
Artículo
Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity
(MDPI, 2020)
Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal ...