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Enhanced Gene Regulation by Cooperation between mRNA Decay and Gene Transcription
(Elsevier, 2023)
It has become increasingly clear in the last few years that gene expression in eukaryotes is not a linear process from mRNA synthesis in the nucleus to translation and degradation in the cytoplasm, but works as a circular ...
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Human Omental Mesothelial Cells Impart an Immunomodulatory Landscape Impeding B- and T-Cell Activation
(MDPI, 2022)
Mesothelial cells form the mesothelium, a simple epithelium lining the walls of serous cavities and the surface of visceral organs. Although mesothelial cells are phenotypically well characterized, their immunoregulatory ...
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Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more
(Oxford University Press, 2009)
The Dam methylase of gamma-proteobacteria and the CcrM methylase of alpha-proteobacteria catalyze an identical reaction (methylation of adenosine moieties using S-adenosyl-methionine as methyl donor) at similar DNA targets ...
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Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium
(The Company of Biologists, 2016)
As time passes, mutations accumulate in the genomes of all living organisms. These changes promote genetic diversity, but also precipitate ageing and the initiation of cancer. Food is a common source of mutagens, but ...
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Translocation events in the evolution of aminoacyl-tRNA synthetases
(National Academy of Sciences, 1996)
We have characterized hisS, the gene encoding the histidyl-tRNA synthetase (HisRS) from the tetraodontoid fish Fugu rubripes. The hisS gene is about 3.5 kbp long and contains 13 exons and 12 introns of 172 bp, on average. ...
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Aging during C. elegans L1 quiescence
(Impact Journals LLC, 2020)
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Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization
(PLOS, 2019)
Expression of ABO and Lewis histo-blood group antigens by the gastrointestinal epithelium is governed by an α-1,2-fucosyltransferase enzyme encoded by the Fut2 gene. Alterations in mucin glycosylation have been associated ...
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The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
(Cold Spring Harbor Laboratory Press, 1997)
The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have high frequencies of DNA repeat recombination and chromosome loss. Here we report that HPR1 is required ...
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Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar ty phimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy
(American Society for Microbiology, 2013-01)
Genome-wide expression analyses have provided clues on how Salmonella proliferates inside cultured macrophages and epithelial cells. However, in vivo studies show that Salmonella does not replicate massively within host ...
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Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88
(Cold Spring Harbor Laboratory Press, 2011)
The filamentous fungus Aspergillus niger exhibits great diversity in its phenotype. It is found globally, both as marine and terrestrial strains, produces both organic acids and hydrolytic enzymes in high amounts, and some ...