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Mostrando ítems 11-14 de 14
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DNA end resection requires constitutive sumoylation of CtIP by CBX4
(Nature Publishing Group, 2017)
DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and homologous recombination. The decision between them depends on the activation of the DNA resection ...
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A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
(Nature Publishing Group, 2016)
There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these ...
Artículo
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CtIP Mutations Cause Seckel and Jawad Syndromes
(Public Library of Science, 2011)
Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. Genetically, it constitutes a heterogeneous condition, with several loci mapped (SCKL1-5) but only three ...
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The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair
(Elsevier, 2018)
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A. UBE4A’s ...