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Mostrando ítems 61-66 de 66
Artículo
Survey of Early-Diverging Lineages of Fungi Reveals Abundant and Diverse Mycoviruses
(American Society for Microbiology, 2020)
Mycoviruses are widespread and purportedly common throughout the fungal kingdom, although most are known from hosts in the two most recently diverged phyla, Ascomycota and Basidiomycota, together called Dikarya. To augment ...
Artículo
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
(Springer Nature, 2021)
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. ...
Artículo
Waddington's Landscapes in the Bacterial World
(Frontiers Media, 2021)
Conrad Waddington's epigenetic landscape, a visual metaphor for the development of multicellular organisms, is appropriate to depict the formation of phenotypic variants of bacterial cells. Examples of bacterial differentiation ...
Artículo
WHI-2 Regulates Intercellular Communication via a MAP Kinase Signaling Complex
(Frontiers Media, 2020)
he formation of the fungal mycelial network is facilitated by somatic cell fusion of germinating asexual spores (or germlings). Neurospora crassa germlings in close proximity display chemotropic growth that is dependent ...
Artículo
Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
(Oxford University Press, 2020)
DNA topoisomerase II (TOP2) is a major DNA metabolic enzyme, with important roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the target of a class of anticancer ...
Artículo
Copy Number Heterogeneity in the Virulence Plasmid of Salmonella enterica
(Frontiers Media, 2020)
Quantitative PCR analysis shows that the virulence plasmid of Salmonella enterica serovar Typhimurium (pSLT) is a low-copy-number plasmid, with 1–2 copies per chromosome. However, fluorescence microscopy observation of ...