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Mostrando ítems 21-30 de 53
Artículo
A new connection of mRNP biogenesis and export with transcription-coupled repair
(Oxford University Press, 2007)
Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution of mRNP biogenesis and export in transcription-coupled repair (TCR). Interestingly, mutants of THO, ...
Artículo
Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery
(Rockefeller University Press, 2009)
The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in mammalian cells, binds the tumor suppressor protein BRCA2. Here, we describe a new function for yeast ...
Artículo
XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
(MDPI, 2022)
Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution eukaryotic cells have evolved a chemically reversible modification of the cytosine base. These dynamic ...
Artículo
Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development
(BMC, 2022)
Background After embryonic development, Caenorhabditis elegans progress through for larval stages, each of them finishing with molting. The repetitive nature of C. elegans postembryonic development is considered an ...
Artículo
Analysis of Salmonella lineage-specific traits upon cell sorting
(Frontiers Media SA, 2023-03-29)
Microbial cell individuality is receiving increasing interest in the scientific community. Individual cells within clonal populations exhibit noticeable phenotypic heterogeneity. The advent of fluorescent protein technology ...
Artículo
Molybdenum cofactor (chlorate-resistant) mutants of Klebsiella pneumoniae M5al can use hypoxanthine as the sole nitrogen source.
(American Society for Microbiology, 1992)
Selection for chlorate resistance yields mol (formerly chl) mutants with defects in molybdenum cofactor synthesis. Complementation and genetic mapping analyses indicated that the Klebsiella pneumoniae mol genes are ...
Artículo
The presence of glutamate dehydrogenase is a selective advantage for the cyanobacterium Synechocystis sp. strain PCC 6803 under nonexponential growth conditions
(American Society for Microbiology, 1999)
he unicellular cyanobacterium Synechocystis sp. strain PCC 6803 has two putative pathways for ammonium assimilation: the glutamine synthetase- glutamate synthase cycle, which is the main one and is finely regulated by the ...
Artículo
A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region
(2006)
The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in the reassembly of nucleosomes traversed by RNA polymerase II. Since several features of chromatin ...
Artículo
Contribution of phenotypic heterogeneity to adaptive antibiotic resistance
(2014)
Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after ...
Artículo
The Fungal Protein Mes1 Is Required for Morphogenesis and Virulence in the Dimorphic Phytopathogen Ustilago maydis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Polarized growth is a defining property of filamentous fungi, which plays an important role in different aspects of their biology, including virulence. However, little information is available about the determinants of ...