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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
(CELL PRESS (Elsevier), 2024)
During genome duplication, replication forks (RFs) can be stalled by different obstacles or by depletion of replication factors or nucleotides. A limited number of histone post-translational modifications at stalled RFs ...
PhD Thesis
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Study of Pol5 protein from Saccharomyces cerevisiae and its human ortholog MYBBP1A in ribosome biogenesis
(2024-04-10)
Los ribosomas son los orgánulos celulares que llevan a cabo el llamado proceso de traducción, en el cual las proteínas se sintetizan utilizando la información codificada en los RNA mensajeros (mRNAs). Los ribosomas están ...
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Functional characterization and structural modelling of Helianthus annuus (sunflower) ketoacyl-CoA synthases and their role in seed oil composition
(Springer Nature, 2019)
Main conclusion: The enzymes HaKCS1 and HaKCS2 are expressed in sunflower seeds and contribute to elongation of C18 fatty acids, resulting in the C20–C24 fatty acids in sunflower oil. Most plant fatty acids are produced ...
PhD Thesis
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Unraveling the connection between centrosomes and the DNA damage response
(2023-06-20)
Centrosomes act as the major microtubule (MT) organizing centers (MTOC) in most animal cells. Structural or numerical defects in this organelle are associated with chromosome missegregation, polarity defects and ...
PhD Thesis
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Estudio de asimetrías asociadas al huso mitótico de Saccharomyces cerevisiae: nuevos reguladores del posicionamiento del huso y la herencia no aleatoria de los centros organizadores de microtúbulos
(2020-01-24)
La división celular asimétrica es un tipo particular de división en la que se generan dos células de distinto tamaño, contenido, función y/o destino. Este tipo de división es particularmente relevante durante los procesos ...
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Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae
(Public Library of Science, 2014)
During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. The 3′-end processing machinery involves different proteins, this function being crucial to cell ...
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Regulation of finP transcription by DNA adenine methylation in the virulence plasmid of Salmonella enterica
(American Society for Microbiology, 2005-08)
DNA adenine methylase (Dam -) mutants of Salmonella enterica serovar Typhimurium contain reduced levels of FinP RNA encoded on the virulence plasmid. Dam methylation appears to regulate finP transcription, rather than FinP ...
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Fusarium photoreceptors
(MDPI, 2023-03-04)
Light is an important modulating signal in fungi. Fusarium species stand out as research models for their phytopathogenic activity and their complex secondary metabolism. This includes the synthesis of carotenoids, whose ...
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
(Cell Press, 2023-08-03)
To maintain genome integrity, cells must accurately duplicate their genome and repair DNA lesions when they occur. To uncover genes that suppress DNA damage in human cells, we undertook flow-cytometry-based CRISPR-Cas9 ...
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Lack of reelin modifies the gene expression in the small intestine of mice
(Springer Nature, 2012)
We recently demonstrated that the mucosa of the small intestine of the rat expresses reelin and some components of its signaling system. The current study evaluates whether reelin affects the intestinal gene expression ...