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Tesis Doctoral
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Insights into RNA-mediated genome instability by altering ALY expression and the use of new drugs
(2023-04-12)
Las células han desarrollado una serie de mecanismos que utilizan de forma coordinada para mantener la integridad del genoma y permitir una correcta transmisión del material genético a su descendencia. Sin embargo, deben ...
Artículo
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The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription
(Oxford University Press, 2014)
Bud27, the yeast orthologue of human URI/RMP, is a member of the prefoldin-like family of ATPindependent molecular chaperones. It has recently been shown to mediate the assembly of the three RNA polymerases in an ...
Artículo
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Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants
(BMC, 2019)
BACKGROUND: Aspergillus spp. comprises a very diverse group of lower eukaryotes with a high relevance for industrial applications and clinical implications. These multinucleate species are often cultured for many generations ...
Tesis Doctoral
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Fotomorfogénesis de Phycomices
(1988)
La luz azul regula el desarrollo de los esporangióforos (cuerpos fructíferos) de Phycomyces. Existen dos tipos de esporangióforos, de distintas longitud, necróforos y necróforos. La iluminación continúa de cultivos inoculados ...
Artículo
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AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
(Public Library of Science, 2011)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well as ...
Artículo
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Carotenoid Biosynthesis in Fusarium
(MDPI, 2017)
Many fungi of the genus Fusarium stand out for the complexity of their secondary metabolism. Individual species may differ in their metabolic capacities, but they usually share the ability to synthesize carotenoids, a ...
Artículo
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A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation
(American Society for Cell Biology, 2008)
Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed the existence of an RNA-damage response in yeast. The decay kinetics of GAL1p-driven mRNAs revealed ...
Tesis Doctoral
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Relación de la transcripción con la recombinación entre secuencias repetidas en S. cerevisiae
(1998)
La recombinación genética es un proceso fundamental en el metabolismo del ADN en todos los organismos vivos. Existen multitud de procesos biológicos en los que la recombinación está directamente implicada.
Artículo
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A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae
(Oxford University Press, 2021)
Proteostasis needs to be tightly controlled to meet the cellular demand for correctly de novo folded proteins and to avoid protein aggregation. While a coupling between translation rate and co-translational folding, likely ...
Artículo
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R Loops: From Physiologicalto Pathological Roles
(Elsevier, 2019-10-17)
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating ...