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Mostrando ítems 411-420 de 685
Artículo
A eukaryotic-like 3′ untranslated region in Salmonella enterica hilD mRNA
(Oxford University Press, 2014)
Long 3' untranslated regions (3'UTRs) are common in eukaryotic mRNAs. In contrast, long 3'UTRs are rare in bacteria, and have not been characterized in detail. We describe a 3'UTR of 310 nucleotides in hilD mRNA, a transcript ...
Artículo
Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes
(EMBO Press, 2009)
For efficient transcription, RNA PolII must overcome the presence of nucleosomes. The p38-related MAPK Hog1 is an important regulator of transcription upon osmostress in yeast and thereby it is involved in initiation and ...
Artículo
Nucleo-cytoplasmic Shuttling of RNA-binding Factors: mRNA Buffering and Beyond
(Elsevier, 2022)
Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained by tight controls that act on both nuclear ...
Tesis Doctoral
Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN
(2017-06-06)
DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous genotoxic stresses. There are two major and alternative pathways to repair DSBs: non-homologous ...
Tesis Doctoral
Regulation of blocked-DSB repair by DNA-PKcs and ATM kinases
(2019-11-08)
Dada la amenaza que suponen las roturas del ADN de doble cadena para la integridad del genoma, conocer los mecanismos moleculares implicados de su reparación es extremadamente relevante. En particular, las estructuras de ...
Artículo
Bile-induced peptidoglycan remodelling in Salmonella enterica
(Blackwell Publishing, 2015)
Changes in the peptidoglycan (PG) structure of Salmonella enterica are detected in the presence of a sublethal concentration of sodium deoxycholate (DOC): (i) lower proportions of Braun lipoprotein (Lpp)-bound muropeptides; ...
Artículo
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
(Oxford University Press, 2017)
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and ...
Artículo
Programmed heterogeneity: Epigenetic mechanisms in bacteria
(Elsevier, 2013)
Contrary to the traditional view that bacterial populations are clonal, single-cell analysis reveals that phenotypic heterogeneity is common in bacteria. Formation of distinct bacterial lineages appears to be frequent ...
Artículo
The fungal type II myosin in Penicillium marneffei, MyoB, is essential for chitin deposition at nascent septation sites but not actin localization
(American Society for Microbiology, 2011-03)
Cytokinesis is essential for proliferative growth but also plays equally important roles during morphogenesis and development. The human pathogen Penicillium marneffei is capable of dimorphic switching in response to ...
Artículo
SNRPD2 Is a Novel Substrate for the Ubiquitin Ligase Activity of the Salmonella Type III Secretion Effector SlrP
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
SlrP is a protein with E3 ubiquitin ligase activity that is translocated by Salmonella enterica serovar Typhimurium into eukaryotic host cells through a type III secretion system. A yeast two-hybrid screen was performed ...