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Prognostic value of CtIP/RBBP8 expression in breast cancer
(Wiley Open Access, 2013)
CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several ...
Article
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A Live Salmonella Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosa
(American Society for Microbiology, 2019)
Pseudomonas aeruginosa is a common Gram-negative opportunistic pathogen that is intrinsically resistant to a wide range of antibiotics. The development of a broadly protective vaccine against P. aeruginosa remains a major ...
Article
Article
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Final pre-40s maturation depends on the functional integrity of the 60s subunit ribosomal protein l3
(Public Library of Science, 2014)
Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. We report that the rpl3[W255C] allele, which affects the affinity and function of translation ...
Article
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What causes an RNA-DNA hybrid to compromise genome integrity?
(Elsevier, 2019)
Transcription is a source of genome instability that stimulates mutation and recombination. Part of the damage produced by transcription is mediated by R-loops, non-B DNA structures that normally form by the re-annealing ...
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Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
(Public Library of Science, 2009)
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed ...
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The Cell Wall Integrity Pathway Contributes to the Early Stages of Aspergillus Fumigatus Asexual Development
(American Society for Microbiology, 2020)
Aspergillus fumigatus is a major cause of human disease. The survival of this fungus is dependent on the cell wall organization and function of its components. The cell wall integrity pathway (CWIP) is the primary signaling ...
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Use of chitin and chitosan to produce new chitooligosaccharides by chitinase Chit42: enzymatic activity and structural basis of protein specificity
(BioMed Central, 2018)
Background Chitinases are ubiquitous enzymes that have gained a recent biotechnological attention due to their ability to transform biological waste from chitin into valued chito-oligomers with wide agricultural, ...
PhD Thesis
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Modificación de la biosíntesis de carotenoides de Gibberella Fujikuroi
(1987)
La tesis describe los efectos mutagénicos de la n-metil-n'-nitro-n-nitrosogua-nidina y la radiación ultravioleta sobre Gibberella fujikuroi. Se describen las caracteristicas de distintos tipos de mutantes alterados en la ...
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A new challenge for data analytics: transposons
(BMC, 2022)