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Artículo
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An Evolutionary Perspective of the Lipocalin Protein Family
(Frontiers Media, 2021)
The protein family of Lipocalins is ubiquitously present throughout the tree of life, with the exception of the phylum Archaea. Phylogenetic relationships of chordate Lipocalins have been proposed in the past based on ...
Artículo
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Regulation of conjugal transfer by Lrp and dam methylation in plasmid R100
(Sociedad Española de Microbiología, 2005-12)
Conjugal transfer of the F-like plasmid R100 occurs at higher frequencies in the absence of DNA adenine methylation. Lower levels of R100-encoded FinP RNA were found in a Dam- host, suggesting that Dam methylation regulates ...
Artículo
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Speed matters: How subtle changes in DNA end resection rate affect repair
(Taylor & Francis, 2015)
The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, ...
Artículo
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Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae
(2003)
We investigated the formation of X-shaped molecules consisting of joint circular minichromosomes (joint molecules) in Saccharomyces cerevisiae by two-dimensional neutral/neutral gel electrophoresis of psoralen-cross-linked ...
Artículo
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DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar typhimurium
(American Society for Microbiology, 2006)
Transcriptomic analyses during growth in Luria-Bertani medium were performed in strain SL1344 of Salmonella enterica serovar Typhimurium and in two isogenic derivatives lacking Dam methylase. More genes were repressed than ...
Tesis Doctoral
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New factors involved in transcription-associated genome instability
(2019-10-23)
El mantenimiento de la integridad del DNA y la transmisión fiel de su información a la descendencia es una prioridad para los seres vivos. Al mismo tiempo, la molécula de DNA es el sustrato de numerosas reacciones vitales ...
Artículo
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TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage
(American Society for Biochemistry and Molecular Biology, 2011-01-07)
Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5′-phosphotyrosyl bond. Although these intermediates are normally transient, they ...
Artículo
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Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
(Oxford University Press, 2018)
The contribution of most ribosomal proteins to ribo- some synthesis has been quite well analysed in Sac- charomyces cerevisiae . However, few yeast riboso- mal proteins still await characterization. Herein, we show ...
Tesis Doctoral
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Inestabilidad genética asociada a R-loops.
(2018-07-06)
La inestabilidad genómica es una patología celular, la cual se produce cuando una célula acumula variaciones genéticas que alteran su genoma. La acción de agentes genotóxicos externos, así como el propio metabolismo celular ...
Patente. Invención
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Producción de giberelinas, GA1 y GA3 mediante fermentaciones con estirpes silvestres del hongo Gibberella Fujikuroi
(Oficina Española de Patentes y Marcas (OEPM), 2006-02-22)
Producción de giberelinas, GA1 y GA3 mediante fermentaciones con estirpes silvestres del hongo Gibberella Fujikuroi. Es objeto de esta invención un método de producción de giberelinas (especialmente GA1 y GA3) mediante estirpes ...