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Artículo
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The Fungal Protein Mes1 Is Required for Morphogenesis and Virulence in the Dimorphic Phytopathogen Ustilago maydis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Polarized growth is a defining property of filamentous fungi, which plays an important role in different aspects of their biology, including virulence. However, little information is available about the determinants of ...
Artículo
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Centriolar Subdistal Appendages Promote Double-strand Break Repair Through Homologous Recombination
(1469-3178, 2023)
The centrosome is a cytoplasmic organelle with roles in microtu-bule organization that has also been proposed to act as a hub forcellular signaling. Some centrosomal components are required forfull activation of the DNA ...
Tesis Doctoral
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Descripción y caracterización de la interacción física entre los complejos MCM y RNR en respuesta a daños en el ADN
(2022-05-24)
El complejo MCM junto con el factor Cdc45 y el complejo GINS forman la helicasa replicativa en eucariotas, cuya actividad es esencial para la viabilidad de la célula y una diana clave en la regulación de la replicación. ...
Tesis Doctoral
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Influence of chromatin factors and DNA-RNA hybrids in the repair of replication-born DSBs
(2021-06-02)
La información genética debe estar almacenada de manera segura en la molécula de ADN. Sin embargo, el ADN está continuamente expuesto a daños que alteran su estructura y secuencia dando lugar al proceso conocido cómo ...
Artículo
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Nucleo-cytoplasmic Shuttling of RNA-binding Factors: mRNA Buffering and Beyond
(Elsevier, 2022)
Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained by tight controls that act on both nuclear ...
Artículo
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SNRPD2 Is a Novel Substrate for the Ubiquitin Ligase Activity of the Salmonella Type III Secretion Effector SlrP
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
SlrP is a protein with E3 ubiquitin ligase activity that is translocated by Salmonella enterica serovar Typhimurium into eukaryotic host cells through a type III secretion system. A yeast two-hybrid screen was performed ...
Artículo
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Evidence for Involvement of the Salmonella enterica Z-Ring Assembly Factors ZapA and ZapB in Resistance to Bile
(Frontiers Media, 2021)
Genes annotated as ygfE and yiiU in the genome of Salmonella enterica serovar Typhimurium encode proteins homologous to Escherichia coli cell division factors ZapA and ZapB, respectively. ZapA− and ZapB− mutants of S. ...
Capítulo de Libro
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Detection of DNA Double-Strand Breaks byγ-H2AX Immunodetection
(Humana, 2020)
DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage and a cause of geneticinstability as they can lead to mutations, genome rearrangements, or loss of genetic material when notproperly repaired. ...
Artículo
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The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
(Frontiers Media S.A., 2021)
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated ...
Artículo
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Quantitative analysis of protein-RNA interactions in fission yeast
(Elsevier, 2022)
Characterizing the interactions between RNAs and proteins in vivo is key to better understand how organisms regulate gene expression. Here, we describe a robust and quantitative protocol to measure specific RNA-protein ...